Burden of community-associated Clostridioides difficile infection in southeastern United States: a population-based study.

Autor: Younas M; University of South Carolina School of Medicine, Columbia, SC, USA. drmariamyounas@gmail.com.; Department of Medicine, Palmetto Health University of South Carolina Medical Group, Columbia, SC, USA. drmariamyounas@gmail.com., Royer J; Health and Demographics Division, South Carolina Revenue and Fiscal Affairs Office, Columbia, SC, USA., Weissman SB; University of South Carolina School of Medicine, Columbia, SC, USA.; Department of Medicine, Palmetto Health University of South Carolina Medical Group, Columbia, SC, USA., Waites KS; South Carolina Department of Health and Environmental Control, Columbia, SC, USA., Dash S; University of South Carolina School of Medicine, Columbia, SC, USA.; Department of Medicine, Palmetto Health University of South Carolina Medical Group, Columbia, SC, USA., Rac H; Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina College of Pharmacy, Columbia, SC, USA.; Department of Pharmacy, Prisma Health Richland, Columbia, SC, USA., Bookstaver PB; Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina College of Pharmacy, Columbia, SC, USA.; Department of Pharmacy, Prisma Health Richland, Columbia, SC, USA., Justo JA; Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina College of Pharmacy, Columbia, SC, USA.; Department of Pharmacy, Prisma Health Richland, Columbia, SC, USA., Bell L; South Carolina Department of Health and Environmental Control, Columbia, SC, USA., Maki A Jr; South Carolina Department of Health and Environmental Control, Columbia, SC, USA., Al-Hasan MN; University of South Carolina School of Medicine, Columbia, SC, USA. majdi.alhasan@uscmed.sc.edu.; Department of Medicine, Palmetto Health University of South Carolina Medical Group, Columbia, SC, USA. majdi.alhasan@uscmed.sc.edu.
Jazyk: angličtina
Zdroj: Infection [Infection] 2020 Feb; Vol. 48 (1), pp. 129-132. Date of Electronic Publication: 2019 Nov 01.
DOI: 10.1007/s15010-019-01368-5
Abstrakt: Objectives: This cross-sectional population-based study aims to determine overall incidence rate of Clostridioides difficile infection (CDI) in the State of South Carolina and provide an estimated cost of hospitalization due to community-associated CDI (CA-CDI).
Methods: All CDI cases in South Carolina were identified through National Healthcare Safety Network (NHSN) and the South Carolina Infectious Disease and Outbreak Network (SCION) from January 1, 2015 to June 30, 2016, excluding infants < 1 year of age.
Results: During the 18-month study period, 10,254 CDI events were identified in South Carolina residents with an overall incidence rate of 139/100,000 person-years. Over one-half of CDI cases were CA-CDI (5192; 51%) with an incidence rate of 71/100,000 person-years. Among patients with CA-CDI, 2127 (41%) required hospitalization with a median length of stay of 5 days. The annual burden of CA-CDI in South Carolina was estimated to be 9282 hospital days and $16,217,295 in hospitalization costs.
Conclusion: The incidence rate of CA-CDI in South Carolina has surpassed both community-onset healthcare facility associated and hospital-onset CDI combined. The heavy burden of CA-CDI justifies dedication of public health resources to combat CDI in ambulatory settings, through antimicrobial stewardship initiatives.
Databáze: MEDLINE
Externí odkaz: