Lack of Detection of the Analgesic Properties of PF-05089771, a Selective Na v 1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects.
Autor: | Siebenga P; Centre for Human Drug Research, Leiden, The Netherlands., van Amerongen G; Centre for Human Drug Research, Leiden, The Netherlands., Hay JL; Centre for Human Drug Research, Leiden, The Netherlands., McDonnell A; Neuroscience and Pain Research Unit, Pfizer WRD, Cambridge, UK., Gorman D; Neuroscience and Pain Research Unit, Pfizer WRD, Cambridge, UK., Butt R; Neuroscience and Pain Research Unit, Pfizer WRD, Cambridge, UK., Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands. |
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Jazyk: | angličtina |
Zdroj: | Clinical and translational science [Clin Transl Sci] 2020 Mar; Vol. 13 (2), pp. 318-324. Date of Electronic Publication: 2019 Nov 12. |
DOI: | 10.1111/cts.12712 |
Abstrakt: | Sodium channel blockers are used for the treatment of pain, but this is limited by the lack of selectivity for different sodium channel subtypes, which can result in central nervous system and cardiovascular side effects. As such, there is special interest in the Na (© 2019 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.) |
Databáze: | MEDLINE |
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