| Autor: |
Oliveira MCB; Postgraduate Programme in Clinical Medicine, Federal University of Rio de Janeiro, Rio de Janeiro., Sant'Anna CC; Pediatrics Department, Faculty of Medicine, Instituto de Puericultura e Pediatria Martagão Gesteira, Federal University of Rio de Janeiro, Rio de Janeiro., Luiz RR; Social Medicine Institute, Federal University of Rio de Janeiro, Rio de Janeiro., Soares ECC; Tuberculosis Programme, Secretaria Municipal de Saúde, Rio de Janeiro., Kritski AL; Academic Programme of Tuberculosis, Institute of Thorax Diseases, Faculty of Medicine Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2019 Oct 01; Vol. 23 (10), pp. 1115-1121. |
| DOI: |
10.5588/ijtld.18.0778 |
| Abstrakt: |
SETTING: Rio de Janeiro, RJ, Brazil, a high tuberculosis (TB) burden city. OBJECTIVE: To compare the sociodemographics, clinical characteristics, care process indicators (CPIs) and treatment outcomes among adolescents with pulmonary TB (PTB) and those with PTB + extrapulmonary TB (EPTB), who underwent testing with Xpert ® and sputum culture. DESIGN: This was a retrospective study of data from three national databases from 2014 to 2016 of adolescents (aged 10-18 years) residing and notified in Rio de Janeiro City. Three groups were identified according to their Xpert and culture results: Group 1, Xpert- and culture-positive; Group 2, Xpert-positive and culture-negative; and Group 3, Xpert- and culture-negative. Study CPIs were as follows: the time between 'sample collection and Xpert result release', 'sample collection and treatment initiation' and 'notification and treatment outcome'. RESULTS: Of 258 adolescents included in the study, 223 (86.4%) were in Group 1, 20 (7.8%) in Group 2 and 15 (5.8%) in Group 3. Groups 1 and 2 had a similar profile. Compared to Group 1, Group 3 had a higher proportion of HIV-positive cases (21.4% vs. 3.0%, P = 0.016), adolescents with a hospital diagnosis (53.3% vs. 7.6%, P < 0.001), and PTB + EPTB cases (20% vs. 0.4%; P < 0.001). There were no statistically significant differences in CPIs or treatment outcomes. CONCLUSION: The clinical diagnosis was decisive in more critical or complex patients, despite Xpert-negative results. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
