Postnatal changes in O 2 and CO 2 sensitivity in rodents.

Autor: Dzal YA; Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. Electronic address: y.dzal@uwinnipeg.ca., Sprenger RJ; Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada., Milsom WK; Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2020 Jan; Vol. 272, pp. 103313. Date of Electronic Publication: 2019 Oct 15.
DOI: 10.1016/j.resp.2019.103313
Abstrakt: In rodents, the ventilatory responses to hypoxia (low O 2 ) and hypercarbia (high CO 2 ) change significantly over postnatal development. In hypoxia, most adult rodents increase ventilation and decrease metabolism to some degree. Hypercarbia, however, leads to an increase in ventilation with little, to no change in metabolism. Neonates, on the other hand, respond to hypoxia with a profound metabolic depression, and a severely attenuated ventilatory response. In hypercarbia, they exhibit a strong ventilatory response early in development that blunts, reaches a nadir, and then rises back to the adult-like response, thus, stabilizing postnatally. In this review we discuss how the O 2 and CO 2 ventilatory responses develop in rodents, the possible mechanisms that drive these postnatal changes, and how being raised in a burrow, an environment putatively low in O 2 and high in CO 2 , may affect the development of O 2 and CO 2 sensitivity in rodents.
(Crown Copyright © 2019. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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