| Autor: |
Vodyanova MA; Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation, Moscow, Russia. lab.pochva@mail.ru., Kryatov IA; Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation, Moscow, Russia., Chudakova SB; Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation, Moscow, Russia., Ushakova OV; Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation, Moscow, Russia., Evseeva IS; Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation, Moscow, Russia., Makovetskaya AK; Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation, Moscow, Russia., Mislavsky OV; Center for Strategic Planning and Management of Biomedical Health Risks, Ministry of Health of the Russian Federation, Moscow, Russia. |
| Abstrakt: |
We studied allergenic, immunogenic, and skin-irritating effects of deicing chemicals HCM (Volgograd), Bishofit (Turkmenia), and Nordix-P (Russia) in model experiments on various types of laboratory animals (rats, mice, rabbits). All the studied deicing chemicals exhibited weak immunotoxic activity and in high doses can cause delayed-type hypersensitivity reaction that manifested in skin irritant effect on the skin and produced a suppressive effect on the humoral immunity. The modified method for assessing skin irritation proposed by us is more sensitive than standard methods. |
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