Prosthetic Valve Endocarditis with Bartonella washoensis in a Human European Patient and Its Detection in Red Squirrels ( Sciurus vulgaris ).

Autor:	von Loewenich FD; Department of Medical Microbiology and Hygiene, University of Mainz, Mainz, Germany friederike.loewenich@unimedizin-mainz.de., Seckert C; Department of Medical Microbiology and Hygiene, University of Mainz, Mainz, Germany., Dauber E; Department of Medical Microbiology and Hygiene, University of Mainz, Mainz, Germany., Kik MJL; Dutch Wildlife Health Center, Utrecht University, Utrecht, The Netherlands., de Vries A; Center for Infectious Disease Control, National Institute for Public Health and Environment, Bilthoven, The Netherlands., Sprong H; Center for Infectious Disease Control, National Institute for Public Health and Environment, Bilthoven, The Netherlands., Buschmann K; Department of Cardiothoracic and Vascular Surgery, University of Mainz, Mainz, Germany., Aardema ML; Department of Biology, Montclair State University, Montclair, New Jersey, USA.; Sackler Institute for Comparative Genomics, The American Museum of Natural History, New York, New York, USA., Brandstetter M; Department of Medical Microbiology and Hygiene, University of Mainz, Mainz, Germany.
Jazyk:	angličtina
Zdroj:	Journal of clinical microbiology [J Clin Microbiol] 2019 Dec 23; Vol. 58 (1). Date of Electronic Publication: 2019 Dec 23 (Print Publication: 2019).
DOI:	10.1128/JCM.01404-19
Abstrakt:	Members of the genus Bartonella are fastidious Gram-negative facultative intracellular bacteria that are typically transmitted by arthropod vectors. Several Bartonella spp. have been found to cause culture-negative endocarditis in humans. Here, we report the case of a 75-year-old German woman with prosthetic valve endocarditis due to Bartonella washoensis The infecting agent was characterized by sequencing of six housekeeping genes (16S rRNA, ftsZ , gltA , groEL , ribC , and rpoB ), applying a multilocus sequence typing (MLST) approach. The 5,097 bp of the concatenated housekeeping gene sequence from the patient were 99.0% identical to a sequence from a B. washoensis strain isolated from a red squirrel ( Sciurus vulgaris orientis ) from China. A total of 39% (24/62) of red squirrel ( S. vulgaris ) samples from the Netherlands were positive for the B. washoensis gltA gene variant detected in the patient. This suggests that the red squirrel is the reservoir host for human infection in Europe. (Copyright © 2019 American Society for Microbiology.)
Databáze:	MEDLINE
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