Anti-arthritic potential of ethanol and aqueous extracts of stem bark of Cleistopholis patens on complete Freund's adjuvant-induced rheumatoid arthritis in rats.
| Autor: | Aloke C; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ikwo, Abakaliki, Ebonyi State, Nigeria. Electronic address: chinyere.aloke@funai.edu.ng., Ibiam UA; Department of Biochemistry, Faculty of Sciences, Ebonyi State University, Abakaliki, Nigeria., Orji OU; Department of Biochemistry, Faculty of Sciences, Ebonyi State University, Abakaliki, Nigeria., Ugwuja EI; Department of Biochemistry, Faculty of Sciences, Ebonyi State University, Abakaliki, Nigeria., Ezeani NN; Department of Biochemistry, Faculty of Sciences, Ebonyi State University, Abakaliki, Nigeria., Aja PM; Department of Biochemistry, Faculty of Sciences, Ebonyi State University, Abakaliki, Nigeria., Obasi NA; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Ikwo, Abakaliki, Ebonyi State, Nigeria. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of Ayurveda and integrative medicine [J Ayurveda Integr Med] 2021 Jan-Mar; Vol. 12 (1), pp. 28-34. Date of Electronic Publication: 2019 Oct 09. |
| DOI: | 10.1016/j.jaim.2018.12.009 |
| Abstrakt: | Background: Traditional medicine intervention has been used in rheumatoid arthritis (RA) treatment due to limitations of conventional drugs. Objective: This study aimed at evaluating the anti-arthritic potentials of ethanol and aqueous extracts of stem bark of Cleistopholis patens (SBCP) in complete Freund's adjuvant (CFA) induced rheumatoid arthritis in rats. Materials and Methods: Rheumatoid arthritis was induced in groups 2 to 9 by intradermal injection of 0.1 mlkg -1 chicken type II collagen in CFA into the left hind paw of the rats. Group 1 served as normal control. Group 2 (negative control) received 5 mlkg -1 body weight normal saline while group 3 (positive control) received 10 mg/kg body weight standard drug (indomethacin). Groups 4 to 9 received varied doses of the extracts. After 10 days of RA induction, rats were treated with ethanol and aqueous extracts of SBCP orally at a dose of 400, 600 and 800 mgkg -1 for 21 days. The paw size, body weight changes, inflammatory parameters, lipid peroxidation maker and malondialdehyde (MDA) were assessed. Results: Rheumatoid arthritis induction caused marked (p < 0.05) increase in paw size, inflammatory makers and MDA while significant (p < 0.05) reduction was observed in body weight relative to normal control. Treatment with extracts analogous to indomethacin markedly (p < 0.05) decreased the paw size and caused weight gain while the altered inflammatory parameters and MDA were reversed relative to negative control. Conclusion: The findings suggest that the extracts of SBCP have good antiarthritic potentials comparable to indomethacin and hence could be used in rheumatoid arthritis management. (Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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