One-Pot Metal-Free Synthesis of 3-CF 3 -1,3-Oxazinopyridines by Reaction of Pyridines with CF 3 CO-Acetylenes.

Autor: Muzalevskiy VM; M. V. Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory 1, Moscow 119991, Russian Federation. muzvas@mail.ru., Sizova ZA; M. V. Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory 1, Moscow 119991, Russian Federation. syzova@mail.ru., Belyaeva KV; A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russian Federation. belyaeva@irioch.irk.ru., Trofimov BA; A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., Irkutsk 664033, Russian Federation. boris_trofimov@irioch.irk.ru., Nenajdenko VG; M. V. Lomonosov Moscow State University, Department of Chemistry, Leninskie Gory 1, Moscow 119991, Russian Federation. nenajdenko@gmail.com.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2019 Oct 06; Vol. 24 (19). Date of Electronic Publication: 2019 Oct 06.
DOI: 10.3390/molecules24193594
Abstrakt: The reaction of pyridines with trifluoroacetylated acetylenes was investigated. It was found that the reaction of various pyridines with two molecules of CF 3 CO-acetylenes proceeds under mild metal-free conditions. As a result, efficient stereoselective synthesis of 3-arylethynyl-3-trifluoromethyl-1,3-oxazinopyridines was elaborated. Target heterocycles can be prepared in up to quantitative yields.
Competing Interests: The authors declare no conflicts of interest.
Databáze: MEDLINE
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