Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index.

Autor:	Rios JS; Department of Obstetrics & Gynecology, University of Cincinnati, Cincinnati, Ohio., Greenwood EA; Department of Obstetrics & Gynecology, University of California San Francisco, San Francisco, California., Pavone MEG; Department of Obstetrics & Gynecology, Northwestern University, Chicago, Illinois., Cedars MI; Department of Obstetrics & Gynecology, University of California San Francisco, San Francisco, California., Legro RS; Department of Obstetrics & Gynecology, Pennsylvania State University, Hershey, Pennsylvania., Diamond MP; Department of Obstetrics & Gynecology, Augusta University, Augusta, Georgia., Santoro N; Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado., Sun F; Collaborative Center for Statistics in Science, Yale School of Public Health, New Haven, Connecticut., Robinson RD; Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas., Christman G; Department of Obstetrics and Gynecology, University of Florida, Gainesville, Florida., Zhang H; Collaborative Center for Statistics in Science, Yale School of Public Health, New Haven, Connecticut., Huddleston HG; Department of Obstetrics & Gynecology, University of California San Francisco, San Francisco, California.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2020 Jan 01; Vol. 105 (1).
DOI:	10.1210/clinem/dgz012
Abstrakt:	Context: The relationship between reproductive and cardiometabolic aging is unclear. It is unknown if the relationship differs across different clinical populations. Objective: To determine whether markers of ovarian reserve are associated with cardiometabolic risk in reproductive aged women with unexplained infertility (UI), polycystic ovary syndrome (PCOS), and regularly cycling women (OVA). Design and Setting: Cross-sectional data from 8 US-based academic centers. Participants: Women aged 25-40 from 3 clinical populations: 870 with UI, 640 with PCOS, and 921 community-based OVA. Main Outcome Measures: Multivariable linear regression models were used to relate anti-mullerian hormone (AMH) and antral follicle count with cardiometabolic parameters including body mass index (BMI), waist circumference (WC), fasting glucose and insulin, homeostasis model assessment-insulin resistance (HOMA-IR), lipids, and C-reactive protein. Results: In age and study site-adjusted models, AMH inversely related to BMI in the UI and OVA groups (P = 0.02 and P < 0.001). Among women with PCOS, AMH inversely related to BMI (P < 0.001), and also to WC (P < 0.001), fasting insulin (P < 0.01), HOMA-IR (P < 0.01), triglycerides (P = 0.04), and C-reactive protein (P < 0.001) and directly related to higher total (P = 0.02), low-density lipoprotein (P < 0.01), and high-density lipoprotein cholesterol (P < 0.01). In OVA, AMH also varied inversely with WC (P < 0.001), fasting insulin (P = 0.02), and HOMA-IR (P = 0.02). Adjustment for BMI eliminated associations in the OVA group but in PCOS, the relationship of AMH to total (P = 0.03) and low-density lipoprotein cholesterol (P = 0.003) remained. Conclusion: Associations observed between AMH and cardiometabolic indices are largely explained by BMI in women with and without PCOS. (J Clin Endocrinol Metab XX: 0-0, 2019). (© Endocrine Society 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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