Preterm Perinatal Hypoxia-Ischemia Does not Affect Somatosensory Evoked Potentials in Adult Rats.

Autor: Barkhuizen M; Department of Pediatrics, Maastricht University Medical Centre (MUMC), 6229HX, Maastricht, The Netherlands. m.barkhuizen@maastrichtuniversity.nl.; Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 HX, Maastricht, The Netherlands. m.barkhuizen@maastrichtuniversity.nl.; DST/NWU Preclinical Drug Development Platform, North-West University, Potchefstroom 2531, South Africa. m.barkhuizen@maastrichtuniversity.nl., Vles JSH; Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 HX, Maastricht, The Netherlands. jsh.vles@mumc.nl.; Child Neurology, Maastricht University Medical Centre, 6229 HX, Maastricht, The Netherlands. jsh.vles@mumc.nl., van Mechelen R; Department of Pediatrics, Maastricht University Medical Centre (MUMC), 6229HX, Maastricht, The Netherlands. r.vanmechelen@maastrichtuniversity.nl.; Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 HX, Maastricht, The Netherlands. r.vanmechelen@maastrichtuniversity.nl., Vermeer M; Department of Pediatrics, Maastricht University Medical Centre (MUMC), 6229HX, Maastricht, The Netherlands. marijne.vermeer@gmail.com.; Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 HX, Maastricht, The Netherlands. marijne.vermeer@gmail.com., Kramer BW; Department of Pediatrics, Maastricht University Medical Centre (MUMC), 6229HX, Maastricht, The Netherlands. b.kramer@mumc.nl.; Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 HX, Maastricht, The Netherlands. b.kramer@mumc.nl., Chedraui P; Instituto de Investigación e Innovación de Salud Integral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil 090615, Ecuador. peterchedraui@yahoo.com., Bergs P; Clinical Neurophysiology, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands. p.bergs@mumc.nl., van Kranen-Mastenbroek VHJM; Clinical Neurophysiology, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands. v.kranen.mastenbroek@mumc.nl., Gavilanes AWD; Department of Pediatrics, Maastricht University Medical Centre (MUMC), 6229HX, Maastricht, The Netherlands. danilo.gavilanes@mumc.nl.; Department of Translational Neuroscience, School for Mental Health and Neuroscience (MHeNs), Maastricht University, 6229 HX, Maastricht, The Netherlands. danilo.gavilanes@mumc.nl.; Instituto de Investigación e Innovación de Salud Integral, Facultad de Ciencias Médicas, Universidad Católica de Santiago de Guayaquil, Guayaquil 090615, Ecuador. danilo.gavilanes@mumc.nl.
Jazyk: angličtina
Zdroj: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2019 Sep 18; Vol. 9 (3). Date of Electronic Publication: 2019 Sep 18.
DOI: 10.3390/diagnostics9030123
Abstrakt: Somatosensory evoked potentials (SSEPs) are a valuable tool to assess functional integrity of the somatosensory pathways and for the prediction of sensorimotor outcome in perinatal injuries, such as perinatal hypoxia-ischemia (HI). In the present research, we studied the translational potential of SSEPs together with sensory function in the male adult rat with perinatal HI compared to the male healthy adult rat. Both somatosensory response and evoked potential were measured at 10-11 months after global perinatal HI. Clear evoked potentials were obtained, but there were no group differences in the amplitude or latency of the evoked potentials of the preceding sensory response. The bilateral tactile stimulation test was also normal in both groups. This lack of effect may be ascribed to the late age-of-testing and functional recovery of the rats.
Databáze: MEDLINE
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