A case of bizarre posttransplant anti-glomerular basement membrane disease.

Autor: Olewicz-Gawlik A; Department of Infectious Diseases, Hepatology and Acquired Immune Deficiencies, Poznan University of Medical Sciences, Poland.; Department of Anatomy and Histology, University of Zielona Góra, Poland., Żeromski J; Department of Immunology, Poznan University of Medical Sciences, Poland., Świerczewska M; Department of Histology and Embryology, Poznan University of Medical Sciences, Poland., Idasiak-Piechocka I; Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Histology Sciences, Poland., Pawlik M; Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Histology Sciences, Poland., Sikorska D; Department of Rheumatology and Rehabilitation, Poznan University of Medical Sciences, Poland., Samara H; Department of Immunology, Poznan University of Medical Sciences, Poland., Oko A; Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Histology Sciences, Poland., Sikora J; Department of Immunology, Poznan University of Medical Sciences, Poland., Dworacki G; Department of Immunology, Poznan University of Medical Sciences, Poland.
Jazyk: angličtina
Zdroj: Central-European journal of immunology [Cent Eur J Immunol] 2019; Vol. 44 (2), pp. 210-213. Date of Electronic Publication: 2019 Jul 30.
DOI: 10.5114/ceji.2019.87074
Abstrakt: The non-collagenous (NC1) domain of α3 and α5 chains of type IV collagen are eminent targets of abnormal immune response in anti-glomerular basement membrane (anti-GBM) disease, which can be diagnosed by the presence of strong linear IgG staining along GBM detected by direct immunofluorescence. The presence of linear GBM fixation in renal allograft is a rare finding. We observed a 33-year-old male with de novo renal failure in a kidney transplant. An examination of a kidney biopsy specimen revealed, in light microscopy, mild mesangial hypercellularity together with mild focal interstitial fibrosis and sparse inflammatory infiltrate. In immunofluorescence microscopy strong linear IgG staining along the capillary walls was seen. Serum anti-GBM antibodies were negative and no mutation in exons coding NC1 domains of α3 and α5 chains of type IV collagen were detected. We described a rare case of a patient with atypical anti-GBM disease in renal allograft, caused probably by the same process which affected the native kidneys.
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE
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