Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.

Autor:	O'Connor T; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany. Electronic address: tracy.oconnor@helmholtz-muenchen.de., Zhou X; Department of Neurology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany; Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China., Kosla J; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany., Adili A; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany., Garcia Beccaria M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany., Kotsiliti E; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany., Pfister D; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany., Johlke AL; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany., Sinha A; Experimental Systems Immunology, Max Planck Institute of Biochemistry, Munich, Germany., Sankowski R; Institute of Neuropathology, Medical Faculty, University of Freiburg, 79085 Freiburg, Germany., Schick M; III. Medical Department, Technical University of Munich, 81675 Munich, Germany., Lewis R; III. Medical Department, Technical University of Munich, 81675 Munich, Germany., Dokalis N; Institute of Neuropathology, Medical Faculty, University of Freiburg, 79085 Freiburg, Germany., Seubert B; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany., Höchst B; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany., Inverso D; Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany., Heide D; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany., Zhang W; Department of Neurology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany., Weihrich P; Institute for Physiological Chemistry, University of Ulm, 89081 Ulm, Germany., Manske K; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany., Wohlleber D; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany., Anton M; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany., Hoellein A; III. Medical Department, Technical University of Munich, 81675 Munich, Germany., Seleznik G; Institute of Neuropathology, University Hospital of Zurich, 8091 Zurich, Switzerland., Bremer J; Institute of Neuropathology, University Hospital of Zurich, 8091 Zurich, Switzerland., Bleul S; Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Albert-Ludwigs University, 79106 Freiburg, Germany., Augustin HG; Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany; European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Scherer F; Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, Albert-Ludwigs University, 79106 Freiburg, Germany., Koedel U; Department of Neurology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany., Weber A; Department of Pathology and Molecular Pathology, University Hospital of Zurich, 8091 Zurich, Switzerland., Protzer U; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany., Förster R; Institute of Immunology, Hannover Medical School, 30625 Hannover, Germany., Wirth T; Institute for Physiological Chemistry, University of Ulm, 89081 Ulm, Germany., Aguzzi A; Institute of Neuropathology, University Hospital of Zurich, 8091 Zurich, Switzerland., Meissner F; Experimental Systems Immunology, Max Planck Institute of Biochemistry, Munich, Germany., Prinz M; Institute of Neuropathology, Medical Faculty, University of Freiburg, 79085 Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany., Baumann B; Institute for Physiological Chemistry, University of Ulm, 89081 Ulm, Germany., Höpken UE; Max Delbrück Center for Molecular Medicine, 13092 Berlin, Germany., Knolle PA; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany., von Baumgarten L; Department of Neurology, Ludwig-Maximilians-University Hospital Munich, 81377 Munich, Germany., Keller U; III. Medical Department, Technical University of Munich, 81675 Munich, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Hematology and Oncology, Charité - Universitätsmedizin Campus Benjamin Franklin, 12200 Berlin, Germany., Heikenwalder M; Institute of Virology, Technical University of Munich, 81675 Munich, Germany; Helmholtz Center Munich, 85764 Neuherberg, Germany; Institute of Molecular Immunology and Experimental Oncology, Technical University of Munich, Ismaningerstraße 22, 81675 Munich, Germany; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 242, 69120 Heidelberg, Germany. Electronic address: m.heikenwaelder@dkfz-heidelberg.de.
Jazyk:	angličtina
Zdroj:	Cancer cell [Cancer Cell] 2019 Sep 16; Vol. 36 (3), pp. 250-267.e9.
DOI:	10.1016/j.ccell.2019.08.001
Abstrakt:	How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adhesion molecules, which increased LCs in the brain but was insufficient to induce CNSL. Astrocyte-derived CCL19 was required for gliosis-induced CNSL. Deleting CCL19 in mice or CCR7 from LCs abrogated CNSL development. Two-photon microscopy revealed LCs transiently entering normal brain parenchyma. Astrocytic CCL19 enhanced parenchymal CNS retention of LCs, thereby promoting CNSL formation. Aged, gliotic wild-type mice were more susceptible to forming CNSL than young wild-type mice, and astrocytic CCL19 was observed in both human gliosis and CNSL. Therefore, CCL19-CCR7 interactions may underlie an increased age-related risk for CNSL. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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