Normal myocardial native T 1 values in children using single-point saturation recovery and modified look-locker inversion recovery (MOLLI).

Autor: Burkhardt BEU; Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zurich, Switzerland; 3Department of Diagnostic Imaging, University Children's Hospital Zurich, Switzerland., Menghini C; Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zurich, Switzerland; 3Department of Diagnostic Imaging, University Children's Hospital Zurich, Switzerland., Rücker B; Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zurich, Switzerland; 3Department of Diagnostic Imaging, University Children's Hospital Zurich, Switzerland., Kellenberger CJ; Children's Research Center, University Children's Hospital Zurich, Switzerland; 3Department of Diagnostic Imaging, University Children's Hospital Zurich, Switzerland., Valsangiacomo Buechel ER; Pediatric Cardiology, Pediatric Heart Center, Department of Surgery, University Children's Hospital Zurich, Switzerland.; Children's Research Center, University Children's Hospital Zurich, Switzerland; 3Department of Diagnostic Imaging, University Children's Hospital Zurich, Switzerland.
Jazyk: angličtina
Zdroj: Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2020 Mar; Vol. 51 (3), pp. 897-903. Date of Electronic Publication: 2019 Sep 11.
DOI: 10.1002/jmri.26910
Abstrakt: Background: T 1 mapping is useful to quantify diffuse myocardial processes such as fibrosis, edema, storage disorders, or hemochromatosis. Normal pediatric myocardial T 1 values are scarce using modified Look-Locker inversion recovery (MOLLI) sequences and unavailable using Smart1Map, a single-point saturation recovery sequence that measures true T 1 .
Purpose/hypothesis: To establish normal pediatric myocardial T 1 values by Smart1Map and to compare them with T 1 by MOLLI.
Study Type: Prospective cohort study.
Subjects: Thirty-four children and adolescents aged 8-18 years (14 males) without cardiovascular or inflammatory diseases.
Field Strength/sequences: 1.5T, MOLLI, Smart1Map.
Assessment: Mean T 1 values of the left ventricular myocardium, the interventricular septum, and the blood pool were measured with MOLLI and Smart1Map in basal, mid-ventricular, and apical short axis slices.
Statistical Tests: T 1 values were compared between locations and methods by paired samples t-tests, Wilcoxon signed ranks test, repeated-measures analysis of variance (ANOVA), or Friedman's test. Pearson's correlation coefficient was calculated. For interobserver variability, intraclass correlation coefficients and coefficients of variation were calculated, and Bland-Altman analyses were performed.
Results: T 1 values were longer by Smart1Map than by MOLLI in all measured locations (myocardium: 1191-1221 vs. 990-1042 msec; all P < 0.001). T 1 in basal vs. mid-ventricular slices differed both by MOLLI and by Smart1Map for myocardium and for blood (all P < 0.001). Myocardial T 1 did not correlate with age, heart rate, right or left ventricular ejection fraction (all P > 0.05) by either method. Septal vs. total myocardial T 1 values in each slice did not differ by MOLLI (basal P = 0.371; mid-ventricular P = 0.08; apical P = 0.378) nor by Smart1Map (basal P = 0.056; mid-ventricular P = 0.918; apical P = 0. 392), after artifacts had been carefully excluded.
Data Conclusion: We established pediatric normal native T 1 values using the Smart1Map sequence and compared the results with T 1 mapping with MOLLI. Septal T 1 values did not differ from total myocardial T 1 values in each of the myocardial slices.
Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:897-903.
(© 2019 International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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