Graviola Fruit Bar Added Acerola By-Product Extract Protects Against Inflammation and Nociception in Adult Zebrafish ( Danio rerio ).

Autor: Silva LMRD; Department of Food Engineering, Federal University of Ceará, Fortaleza, Ceará, Brazil., Lima JDSS; Department of Food Engineering, Federal University of Ceará, Fortaleza, Ceará, Brazil., Magalhães FEA; Laboratory of Bioprospection of Natural Products and Biotechnology (LBPNB), Tauá, Ceará, Brazil., Campos AR; Center of Experimental Biology (NUBEX), University of Fortaleza, Fortaleza, Ceará, Brazil., Araújo JIF; Laboratory of Bioprospection of Natural Products and Biotechnology (LBPNB), Tauá, Ceará, Brazil., Batista FLA; Laboratory of Bioprospection of Natural Products and Biotechnology (LBPNB), Tauá, Ceará, Brazil., Araújo SMB; Laboratory of Bioprospection of Natural Products and Biotechnology (LBPNB), Tauá, Ceará, Brazil., Sousa PHM; Culture and Art Institute, Federal University of Ceará, Fortaleza, Ceará, Brazil., Lima GC; Faculty of Medicine, State University of Ceará, Fortaleza, Ceará, Brazil.; Novo Tempo Itapipoca Faculty (FNTI) - Itatipoca, Ceará, Brazil., Holanda DKR; Department of Food Engineering, Federal University of Ceará, Fortaleza, Ceará, Brazil., Rolim RC; Department of Food Engineering, Federal University of Ceará, Fortaleza, Ceará, Brazil., Figueiredo RW; Department of Food Engineering, Federal University of Ceará, Fortaleza, Ceará, Brazil., Figueiredo EAT; Department of Food Engineering, Federal University of Ceará, Fortaleza, Ceará, Brazil., Duarte ASG; Department of Morphology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., Ricardo NMPS; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Jazyk: angličtina
Zdroj: Journal of medicinal food [J Med Food] 2020 Feb; Vol. 23 (2), pp. 173-180. Date of Electronic Publication: 2019 Sep 09.
DOI: 10.1089/jmf.2019.0078
Abstrakt: Studies involving foods associated with pain reversal and anti-inflammatory effects using zebrafish are rarely reported in the literature. This study aimed to evaluate the effect of graviola ( Annona muricata L.) fruit bar (GFB) and GFB added with acerola ( Malpighia glabra L) seed extract (ASE) on acute nociception and abdominal inflammation in adult zebrafish ( Danio rerio) . Acute nociception was induced by formalin, capsaicin, cinnamaldehyde, acidic saline, glutamate (cutaneous models), and hypertonic saline (corneal model), and inflammation was induced by carrageenan. Both GFB and ASE exhibited antinociceptive effect modulated by the nitrergic system, guanylate cyclase, and transient receptor potential ankyrin 1 and acid-sensing ion channels. The antinociceptive effect of GFB also appears to be modulated by the opioid system and glutamatergic receptors (N-methyl-D-aspartate receptor). Only ASE presented corneal antinociceptive effect. Both samples showed anti-inflammatory effect, being more significant the effect of GFB. The addition of acerola by-product extract in GFB results in a product with greater biological potential.
Databáze: MEDLINE