Diurnal rodents as pertinent animal models of human retinal physiology and pathology.

Autor: Verra DM; Department of Neurobiology of Rhythms, Institut des Neurosciences Cellulaires et Intégratives (INCI), CNRS UPR 3212, Strasbourg, France., Sajdak BS; Morgridge Institute for Research, Madison, WI, USA., Merriman DK; Department of Biology, University of Wisconsin Oshkosh, Oshkosh, WI, USA., Hicks D; Department of Neurobiology of Rhythms, Institut des Neurosciences Cellulaires et Intégratives (INCI), CNRS UPR 3212, Strasbourg, France. Electronic address: david.hicks@inci-cnrs.unistra.fr.
Jazyk: angličtina
Zdroj: Progress in retinal and eye research [Prog Retin Eye Res] 2020 Jan; Vol. 74, pp. 100776. Date of Electronic Publication: 2019 Sep 06.
DOI: 10.1016/j.preteyeres.2019.100776
Abstrakt: This presentation will survey the retinal architecture, advantages, and limitations of several lesser-known rodent species that provide a useful diurnal complement to rats and mice. These diurnal rodents also possess unusually cone-rich photoreceptor mosaics that facilitate the study of cone cells and pathways. Species to be presented include principally the Sudanian Unstriped Grass Rat and Nile Rat (Arvicanthis spp.), the Fat Sand Rat (Psammomys obesus), the degu (Octodon degus) and the 13-lined ground squirrel (Ictidomys tridecemlineatus). The retina and optic nerve in several of these species demonstrate unusual resilience in the face of neuronal injury, itself an interesting phenomenon with potential translational value.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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