[Liver transplantation and acute failure in chronic liver disease].

Autor:	Flattet Y; Service de gastroentérologie et hépatologie, Département des spécialités de médecine, HUG, 1211 Genève 14., Giostra E; Service de gastroentérologie et hépatologie, Département des spécialités de médecine, HUG, 1211 Genève 14., Spahr L; Service de gastroentérologie et hépatologie, Département des spécialités de médecine, HUG, 1211 Genève 14.
Jazyk:	francouzština
Zdroj:	Revue medicale suisse [Rev Med Suisse] 2019 Aug 28; Vol. 15 (660), pp. 1496-1499.
Abstrakt:	Acute cirrhotic decompensation is characterized by a rapid and sudden deterioration of hepatocellular function. It may be associated with secondary failure of one or more organs. The definition and understanding of a complex cirrhotic decompensation with multi-organ damage, is still poorly defined. This entity is currently called Acute on Chronic Liver Failure (ACLF). Depending on the number of affected organs, decompensation is classified into 4 stages, from 0 to 4. Mortality is proportional to the number of failed organs, with mortality from 50 % to 80 % at 30 days when 3 or more organs are affected. The interest of liver transplantation in the most severe forms, which has been debated for a long time, seems to be a safe alternative with good results in well selected patients. Competing Interests: Les auteurs n’ont déclaré aucun conflit d’intérêt en relation avec cet article.
Databáze:	MEDLINE
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