In vitro bactericidal activity of amoxicillin combined with different cephalosporins against endocarditis-associated Enterococcus faecalis clinical isolates.

Autor:	Peiffer-Smadja N; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Assistance-Publique Hôpitaux de Paris, Paris, France.; Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France., Guillotel E; CHU de Rennes, Service de Bactériologie-Hygiène hospitalière, Rennes, France., Luque-Paz D; CHU de Rennes, Service de Bactériologie-Hygiène hospitalière, Rennes, France., Maataoui N; Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France.; Laboratoire de Bactériologie, Hôpital Bichat-Claude Bernard, Assistance-Publique Hôpitaux de Paris, Paris, France., Lescure FX; Service de Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, Assistance-Publique Hôpitaux de Paris, Paris, France.; Inserm, IAME, UMR 1137, Université Paris Diderot, Paris, France., Cattoir V; CHU de Rennes, Service de Bactériologie-Hygiène hospitalière, Rennes, France.; CNR de la Résistance aux Antibiotiques (laboratoire associé 'Entérocoques'), Rennes, France.; Unité Inserm U1230, Université de Rennes 1, Rennes, France.
Jazyk:	angličtina
Zdroj:	The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2019 Dec 01; Vol. 74 (12), pp. 3511-3514.
DOI:	10.1093/jac/dkz388
Abstrakt:	Background: The combination of amoxicillin with cefazolin could be an interesting regimen for the empirical therapy of severe infective endocarditis, but its activity against enterococci is unknown. Objectives: To evaluate in vitro the bactericidal activity of the combination of amoxicillin with different cephalosporins including cefazolin. Methods: Combinations of amoxicillin (at MIC×¼) with cefazolin, cefotaxime, ceftriaxone, cefepime, ceftaroline or ceftobiprole (at the mean free plasma concentration) were studied using time-kill experiments for 10 endocarditis-associated Enterococcus faecalis strains and 2 reference strains. Results: The combinations amoxicillin/cefazolin, amoxicillin/cefotaxime, amoxicillin/ceftriaxone and amoxicillin/cefepime were synergistic at 12 and 24 h against 12/12 strains and amoxicillin/ceftobiprole and amoxicillin/ceftaroline against 10/12 strains. The combination amoxicillin/cefepime was bactericidal at 24 h against 9/12 strains, the combination amoxicillin/cefazolin against 8/12 strains, the combinations amoxicillin/ceftaroline, amoxicillin/cefotaxime and amoxicillin/ceftobiprole against 7/12 strains and the combination amoxicillin/ceftriaxone against 6/12 strains. Conclusions: The combination amoxicillin/cefazolin is as synergistic and bactericidal in vitro as amoxicillin/cefotaxime or amoxicillin/ceftriaxone against E. faecalis. (© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu