An LRR Receptor-Teneurin System Directs Planar Polarity at Compartment Boundaries.

Autor:	Paré AC; Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA., Naik P; Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA; Weill Cornell Graduate School of Medical Sciences, New York, NY, USA., Shi J; Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA; Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA., Mirman Z; Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA., Palmquist KH; Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA., Zallen JA; Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, New York, NY, USA. Electronic address: zallenj@mskcc.org.
Jazyk:	angličtina
Zdroj:	Developmental cell [Dev Cell] 2019 Oct 21; Vol. 51 (2), pp. 208-221.e6. Date of Electronic Publication: 2019 Sep 05.
DOI:	10.1016/j.devcel.2019.08.003
Abstrakt:	Epithelial cells dynamically self-organize in response to extracellular spatial cues relayed by cell-surface receptors. During convergent extension in Drosophila, Toll-related receptors direct planar polarized cell rearrangements that elongate the head-to-tail axis. However, many cells establish polarity in the absence of Toll receptor activity, indicating the presence of additional spatial cues. Here we demonstrate that the leucine-rich-repeat receptor Tartan and the teneurin Ten-m provide critical polarity signals at epithelial compartment boundaries. The Tartan and Ten-m extracellular domains interact in vitro, and Tartan promotes Ten-m localization to compartment boundaries in vivo. We show that Tartan and Ten-m are necessary for the planar polarity and organization of compartment boundary cells. Moreover, ectopic stripes of Tartan and Ten-m are sufficient to induce myosin accumulation at stripe boundaries. These results demonstrate that the Tartan/Ten-m and Toll receptor systems together create a high-resolution network of spatial cues that guides cell behavior during convergent extension. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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