The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study.

Autor:	Iliadou AN; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Öberg AS; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Pege J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Rodriguez-Wallberg KA; Department of Reproductive Medicine, Division of Gynecology and Reproduction, Karolinska University Hospital, Stockholm, Sweden.; Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden., Olofsson JI; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Holte J; Carl von Linne Kliniken, Uppsala, Sweden.; Department of Women's and Children's Health, Uppsala Universitet, Uppsala, Sweden.; Centre for Reproductive Biology in Uppsala, University of Agricultural Science and Uppsala University, Uppsala, Sweden., Wramsby H; Livio Fertilitetscentrum Kungsholmen, Stockholm, Sweden., Wramsby M; Livio Fertilitetscentrum Gärdet, Stockholm, Sweden., Cnattingius S; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Cesta CE; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden carolyn.cesta@ki.se.; Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2019 Aug 28; Vol. 9 (8), pp. e028866. Date of Electronic Publication: 2019 Aug 28.
DOI:	10.1136/bmjopen-2018-028866
Abstrakt:	Purpose: The Uppsala-Stockholm Assisted Reproductive Techniques (UppStART) study is a prospectively recruited sample of couples undergoing assisted reproduction in Stockholm and Uppsala county in Sweden. The study was initiated to (1) investigate possible changes in the epigenetic profile of infants inferred through the ART procedures and their consequence and (2) to assess the impact of lifestyle and health exposures on treatment outcome. Participants: Recruitment took place between September 2011 and December 2013, and in vitro fertilisation (IVF) cycles initiated and pregnancies conceived during this time were followed until December 2014. The cohort includes 971 participants (n= 514 women; n= 457 men), and 129 pregnancies were achieved from the first IVF cycle included in the study. Findings to Date: Self-reported demographic, health and lifestyle data were collected from a baseline questionnaire, and to assess changes to lifestyle, a follow-up questionnaire was issued at the time of oocyte retrieval, and at subsequent IVF cycles. Questionnaire data were linked to data extracted from medical records. Biological samples were collected at baseline: blood for extraction of serum, plasma and DNA, morning and evening saliva samples for cortisol measurement and at delivery including samples of maternal blood, placenta and amniotic fluid, and cord blood for epigenetic analysis. Future Plans: Through the unique identification number assigned to each Swedish citizen at birth or immigration, UppStART study participants will be linked to the Swedish population-based national and quality registers to provide data from prenatal, obstetrical, neonatal and infant care, and subsequent updates will provide data on childhood health and educational outcomes. Collaboration and use of UppStART data is encouraged, and more information about access can be found at www.ki.se/meb/uppstart. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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