Patients with Type 2 Diabetes Exhibit a More Mineralized Deep Cartilage Layer Compared with Nondiabetic Controls: A Pilot Study.

Autor:	Foreman SC; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.; Department of Radiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany., Ashmeik W; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Baal JD; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Han M; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Bahroos E; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., von Schacky CE; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.; Department of Radiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany., Carl M; GE Healthcare, Chicago, IL, USA., Krug R; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Joseph GB; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA., Link TM; Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Jazyk:	angličtina
Zdroj:	Cartilage [Cartilage] 2021 Dec; Vol. 13 (1_suppl), pp. 428S-436S. Date of Electronic Publication: 2019 Aug 27.
DOI:	10.1177/1947603519870853
Abstrakt:	Objective: To assess differences in biochemical composition of the deep cartilage layer in subjects with type 2 diabetes mellitus (T2DM) and nondiabetic controls using UTE (ultra-short echo time) T2* mapping and to investigate the association of vascular health and UTE T2* measurements. Design: Ten subjects with T2DM matched for age, sex, and body mass index with 10 nondiabetic controls. A 3D UTE sequence with 6 echo times was acquired using 3T magnetic resonance imaging of the knee. For UTE T2* analysis, the deep cartilage layer was segmented and analyzed in 5 compartments (patella, medial, and lateral femur and tibia). The ankle brachial index (ABI) was obtained in all subjects. Linear regression analyses were used to assess associations of T2DM and UTE T2* relaxation times and the associations of ABI measurements and UTE measurements. Results: Compared with nondiabetic controls, T2DM subjects had significantly lower mean T2*-UTE in the patella (mean difference 4.87 ms; 95% confidence interval [CI] 1.09-8.65; P = 0.015), the lateral tibia (mean difference 2.26 ms; 95% CI 0.06-4.45; P = 0.045), and the lateral femur (mean difference 4.96 ms; 95% CI 0.19-9.73; P = 0.043). Independent of diabetic status, subjects with higher ABI values, indicating better vascular health, had higher T2*-UTE of the patella (coefficient 15.2; 95% CI 3.3-21.4; P = 0.017), the medial tibia (coefficient 9.8; 95% CI 1.0-18.6; P = 0.031), and the lateral femur (coefficient 18.8; 95% CI 3.3-34.3; P = 0.021). Conclusions: T2*-UTE measurements of the deep cartilage layer were consistently lower in subjects with T2DM and in subjects with impaired vascular health, likely indicating increased mineralization of this layer.
Databáze:	MEDLINE
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