Novel Route of Synthesis of PCL-CuONPs Composites With Antimicrobial Properties.

Autor: Muñoz-Escobar A; Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez, Chihuahua, Mexico., Ruíz-Baltazar ÁJ; Conacyt-Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México, Juriquilla Querétaro, Mexico., Reyes-López SY; Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Envolvente del PRONAF y Estocolmo s/n, Ciudad Juárez, Chihuahua, Mexico.
Jazyk: angličtina
Zdroj: Dose-response : a publication of International Hormesis Society [Dose Response] 2019 Aug 15; Vol. 17 (3), pp. 1559325819869502. Date of Electronic Publication: 2019 Aug 15 (Print Publication: 2019).
DOI: 10.1177/1559325819869502
Abstrakt: Nanoparticles of metals can be toxic to bacteria, showing biocidal activities at low concentrations. Metal, oxide, or compounds based on copper are applied like antimicrobial agents. The capacity of integration of metallic nanoparticles in polymer matrices has improved the antimicrobial behavior, resulting in the search for composites with increased bactericidal properties. A polycaprolactone (PCL) film polymer with copper oxide nanoparticles (CuONPs) was prepared. Dynamic light scattering analysis showed the sizes from 88 to 97 nm of CuONPs. Scanning electron microscopy (SEM) revealed CuONPs with semispherical shapes with diameter 35 nm. The prepared PCL-CuONPs exhibited a nanoporous structure by SEM. The antibacterial applicability of the composite was evaluated to determine the minimum inhibitory concentration in 6 different bacteria and the experimental tests were carried by disk diffusion and spectrophotometric methods. The PCL-CuONPs exhibit a considerable antibacterial effect in gram-positive bacteria in contrast to gram-negative bacteria. The preparation of PCL-CuONPs was simple, fast, and low cost for practical application as wound dressings.
Competing Interests: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje