| Autor: |
Salvador CEM; Laboratório de Química Metodológica e Orgânica Sintética, Instituto de Química, Universidade de Brasília, Brasília, Brazil., Andrade CKZ; Laboratório de Química Metodológica e Orgânica Sintética, Instituto de Química, Universidade de Brasília, Brasília, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
Frontiers in chemistry [Front Chem] 2019 Jul 30; Vol. 7, pp. 531. Date of Electronic Publication: 2019 Jul 30 (Print Publication: 2019). |
| DOI: |
10.3389/fchem.2019.00531 |
| Abstrakt: |
A continuous flow approach for the synthesis of α-acyloxy ketone derivatives from the corresponding arylglyoxals, isocyanides, and carboxylic acids is described. The target products were obtained in excellent yields in short residence times and with high purities via the first transcription of the microwave-to-flow paradigm to the isocyanide-based Passerini reaction. Furthermore, this methodology allowed a 10-fold scale-up using the same experimental conditions initially established. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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