Age-related histological changes in calcified cartilage and subchondral bone in femoral heads from healthy humans.

Autor: Nielsen AW; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: andreas.wiggers.nielsen@gmail.com., Klose-Jensen R; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: raujen@rm.dk., Hartlev LB; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: louihart@rm.dk., Boel LWT; Institute of Forensic Medicine, Aarhus University, Aarhus, Denmark. Electronic address: lwb@forens.au.dk., Thomsen JS; Institute of Biomedicine - Anatomy, Aarhus University, Aarhus, Denmark. Electronic address: jst@biomed.au.dk., Keller KK; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark. Electronic address: kresten@au.dk., Hauge EM; Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: ellhau@rm.dk.
Jazyk: angličtina
Zdroj: Bone [Bone] 2019 Dec; Vol. 129, pp. 115037. Date of Electronic Publication: 2019 Aug 16.
DOI: 10.1016/j.bone.2019.115037
Abstrakt: Objective: Age is the most important risk factor for osteoarthritis (OA). It is suggested that changes in subchondral bone and calcified cartilage may occur in early OA. Therefore, the aim was to investigate age-related changes in the femoral head composition. We hypothesise that the thickness of the subchondral bone plate decreases with age, while the thickness of the calcified cartilage increases with age as seen in early-stage OA.
Methods: Femoral heads from 29 women (20-74 years) and 32 men (23-78 years), who had died suddenly and unexpectedly, were obtained at autopsy. Individuals with bone or joint diseases or macroscopic abnormal cartilage were excluded. Using design-based stereology, femoral head volume as well as thickness and volume of the calcified cartilage and subchondral bone plate were estimated and correlated to sex and age.
Results: The thickness and volume of the subchondral bone plate were not correlated with age. Calcified cartilage thickness and volume correlated positively with age in women, while the femoral head volume was correlated positively with age in men.
Conclusion: In human femoral heads obtained from a cross-sectional population without macroscopic OA changes, the thickness of the subchondral bone plate did not change with age, which differs from the thinning seen in early OA. Surprisingly, the age-related changes of the volume and thickness of the calcified cartilage and of the volume of the femoral head were different for women and men. This indicate that cartilage and bone metabolism is sex-specific, which may influence ageing of the hip joint.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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