Diagnosis: gastric intestinal metaplasia - what to do next?

Autor:	Graham DY; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine Houston, Texas, USA., Rugge M; Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padova.; Veneto Tumor Registry (RTV), Veneto Regional Authority, Padova, Italy., Genta RM; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine Houston, Texas, USA.
Jazyk:	angličtina
Zdroj:	Current opinion in gastroenterology [Curr Opin Gastroenterol] 2019 Nov; Vol. 35 (6), pp. 535-543.
DOI:	10.1097/MOG.0000000000000576
Abstrakt:	Purpose of Review: One of the most vexing problems for gastroenterologists is what actions to take after receiving a histological diagnosis of gastric intestinal metaplasia. We approach the problem by starting with suggesting a biopsy protocol that ensures obtaining the biopsies required for diagnosis, assessing the status of the gastric mucosa, and effective communication with the pathologist and patient. Recent Findings: The rediscovery and integration of the long history of gastric damage and repair resulting in pseudopyloric metaplasia (called SPEM) into the thinking of investigators working with animal models of gastric cancer has resulted in improved ability to separate changes associated with benign repair from those associated with inflammation-associated gastric carcinogenesis. Summary: Gastric intestinal metaplasia is a potential reversible product of injury and repair and not directly connected with carcinogenesis. Intestinal metaplasia is a biomarker for prior gastric injury and repair. The risk of gastric cancer is best assessed in relation to the severity, extent, and, most importantly, the cause of the atrophic changes.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu