Methylprednisolone pulse therapy plus adjuvant therapy for pemphigus vulgaris: an analysis of 10 years' experience on 312 patients.

Autor: Gheisari M; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Faraji Z; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Dadras MS; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Nasiri S; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Robati RM; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Moravvej H; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Tehranchinia Z; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ghalamkarpour F; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Namazi N; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Nobari NN; Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Dermatologic therapy [Dermatol Ther] 2019 Sep; Vol. 32 (5), pp. e13057. Date of Electronic Publication: 2019 Aug 20.
DOI: 10.1111/dth.13057
Abstrakt: Steroid pulse therapy has shown satisfactory efficacy and safety in treating pemphigus vulgaris (PV). However, there is a paucity of data about the efficacy and safety of methylprednisolone, despite its frequent administration. The aim of this study is to evaluate the efficacy and safety of steroid pulse therapy in treating PV. In this 10-year retrospective cohort study, 312 patients with PV, who had received methylprednisolone pulse therapy, were included. Data of pulse therapy sessions, adjuvant medications, dosages, remission rates, complications, and mortalities were collected from all patients. A total of 276 patients out of 312 underwent the final follow-up at least 6 months after the last session of pulse therapy. Complete remission off therapy was achieved in 83 patients (30%), and 152 patients (55%) had complete remission on therapy. About 29 (10.5%) patients had lesions of pemphigus at the time of the study follow-up, and 26.8% of remained patients were on the minimal therapy. Methylprednisolone pulse therapy could be considered as an option for proper control of PV in severe cases. It might lead to shorter periods of hospitalization and reduce the need to take long-term high-dose oral steroid therapy.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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