Discovery and replication of cerebral blood flow differences in major depressive disorder.

Autor: Cooper CM; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Chin Fatt CR; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Liu P; Department of Radiology, Johns Hopkins University, Baltimore, MD, USA., Grannemann BD; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Carmody T; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Almeida JRC; Department of Psychiatry, Dell Medical School, University of Texas Austin, Austin, TX, USA., Deckersbach T; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Fava M; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA., Kurian BT; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., Malchow AL; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA., McGrath PJ; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY, USA., McInnis M; Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor, MI, USA., Oquendo MA; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Parsey RV; Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA., Bartlett E; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY, USA., Weissman M; Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY, USA., Phillips ML; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lu H; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Radiology, Johns Hopkins University, Baltimore, MD, USA., Trivedi MH; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. Madhukar.Trivedi@utsouthwestern.edu.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2020 Jul; Vol. 25 (7), pp. 1500-1510. Date of Electronic Publication: 2019 Aug 06.
DOI: 10.1038/s41380-019-0464-7
Abstrakt: Major depressive disorder (MDD) is a serious, heterogeneous disorder accompanied by brain-related changes, many of which are still to be discovered or refined. Arterial spin labeling (ASL) is a neuroimaging technique used to measure cerebral blood flow (CBF; perfusion) to understand brain function and detect differences among groups. CBF differences have been detected in MDD, and may reveal biosignatures of disease-state. The current work aimed to discover and replicate differences in CBF between MDD participants and healthy controls (HC) as part of the EMBARC study. Participants underwent neuroimaging at baseline, prior to starting study medication, to investigate biosignatures in MDD. Relative CBF (rCBF) was calculated and compared between 106 MDD and 36 HC EMBARC participants (whole-brain Discovery); and 58 MDD EMBARC participants and 58 HC from the DLBS study (region-of-interest Replication). Both analyses revealed reduced rCBF in the right parahippocampus, thalamus, fusiform and middle temporal gyri, as well as the left and right insula, for those with MDD relative to HC. Both samples also revealed increased rCBF in MDD relative to HC in both the left and right inferior parietal lobule, including the supramarginal and angular gyri. Cingulate and prefrontal regions did not fully replicate. Lastly, significant associations were detected between rCBF in replicated regions and clinical measures of MDD chronicity. These results (1) provide reliable evidence for ASL in detecting differences in perfusion for multiple brain regions thought to be important in MDD, and (2) highlight the potential role of using perfusion as a biosignature of MDD.
Databáze: MEDLINE
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