| Autor: |
Orona-Ortiz A; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad de México, México., Velázquez-Moyado JA; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad de México, México., Pineda-Peña EA; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad de México, México., Balderas-López JL; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad de México, México., Tavares Carvalho JC; Laboratorio de Pesquisa em Farmacos, Curso de Farmacia, Departamento de Ciências Biológicas e da Saúde, Universidade Federal do Amapá, Macapá, Brazil., Navarrete A; Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad de México, México. |
| Abstrakt: |
The gastroprotective effect of a turmeric acetone extract (TAE) ( Curcuma longa L. [Zingiberaceae]) was evaluated and compared against its major curcuminoids; curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Additionally, to demonstrate the importance of the metabolites' ratio in the extract on the synergistic effect, different mixtures were evaluated. An ethanol-induced gastric injury model was used to evaluate the gastroprotection activity in Wistar rats. The pharmacologic interaction analysis was performed using the Combination Index (CI)-Isobologram Equation method. The CI calculated at 0.5 of affected fraction ( fa ) for the TAE indicated a synergistic interaction between its components. However, when the proportion of curcuminoids changed from 3.7:1:10 in TAE to a 1:1:1 ratio, the CI implied an antagonistic effect. The binary combinations of curcuminoids (1:1) also showed an antagonistic interaction. The results of this work suggest that the proportion of curcuminoids in the TAE is crucial for the gastroprotective effect against ethanol-induced damage. |
