Differential neural responding to affective stimuli in 6- to 8-year old children at high familial risk for depression: Associations with behavioral reward seeking.

Autor: Morgan JK; Department of Psychiatry and Department of Psychology, University of Pittsburgh, United States. Electronic address: morganjk@upmc.edu., Silk JS; Department of Psychiatry and Department of Psychology, University of Pittsburgh, United States., Woods BK; Department of Psychology, Boston University, United States., Forbes EE; Department of Psychiatry and Department of Psychology, University of Pittsburgh, United States.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2019 Oct 01; Vol. 257, pp. 445-453. Date of Electronic Publication: 2019 Jul 02.
DOI: 10.1016/j.jad.2019.06.058
Abstrakt: Objective: Children of depressed parents are at increased risk for psychopathology. One putative mechanism of risk appears to be altered processing of emotion-related stimuli. Although prior work has evaluated how adolescent offspring of depressed parents may show blunted reward processing compared to low-risk youth, there has been less attention to how young children with this familial history may differ from their peers during middle childhood, a period of critical socio-affective development METHOD: The current study evaluated 56 emotionally healthy 6-to 8-year children who were deemed at high-risk (n = 25) or low-risk (n = 31) for depression based on maternal history of depression. Children completed a behavioral reward seeking task in the laboratory and an fMRI paradigm assessing neural response to happy faces, a social reward.
Results: Findings demonstrated that high-risk children showed blunted responding to happy faces in the dorsal striatum compared to low-risk children. Further, lower responding in the dorsal striatum and dorsolateral prefrontal cortex was related to lower behavioral reward seeking, but only in high-risk children.
Conclusion: Function within neural reward regions may be altered in high-risk offspring as young as 6- to 8-years of age. Further, neural reward responding may be linked to lower behavioral response to obtain reward in these high-risk offspring.
(Copyright © 2019. Published by Elsevier B.V.)
Databáze: MEDLINE
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