Mixed secondary bacterial infection is associated with severe lesions of chromoblastomycosis in a neglected population from Brazil.

Autor: Marques SG; Hospital Universitário da Universidade Federal do Maranhão, São Luiz, MA, Brazil; Laboratório Cedro, São Luiz, MA, Brazil; Universidade Federal de Minas Gerais, Departamento de Microbiologia, Belo Horizonte, MG, Brazil., Bomfim MRQ; Universidade CEUMA, São Luis, MA, Brazil., Azevedo CMPS; Universidade Federal de Minas Gerais, Departamento de Microbiologia, Belo Horizonte, MG, Brazil; Universidade Federal do Maranhão, São Luis, MA, Brazil., Martins CVB; Centro de Engenharias e Ciências Exatas, UNIOESTE, Toledo, Paraná, Brazil., Marques ACG; Hospital Universitário da Universidade Federal do Maranhão, São Luiz, MA, Brazil., Gonçalves AG; Universidade Federal do Maranhão, São Luis, MA, Brazil., Vicente VA; Universidade Federal do Paraná, Curitiba, PA, Brazil., Dos Santos AM; Universidade Federal do Maranhão, São Luis, MA, Brazil., Costa MC; Universidade Federal de Minas Gerais, Departamento de Microbiologia, Belo Horizonte, MG, Brazil., Freitas GJC; Universidade Federal de Minas Gerais, Departamento de Microbiologia, Belo Horizonte, MG, Brazil., Santos DA; Universidade Federal de Minas Gerais, Departamento de Microbiologia, Belo Horizonte, MG, Brazil. Electronic address: das@ufmg.br., de Resende-Stoianoff MA; Universidade Federal de Minas Gerais, Departamento de Microbiologia, Belo Horizonte, MG, Brazil. Electronic address: maresend@icb.ufmg.br.
Jazyk: angličtina
Zdroj: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2019 Oct; Vol. 95 (2), pp. 201-207. Date of Electronic Publication: 2019 May 31.
DOI: 10.1016/j.diagmicrobio.2019.05.018
Abstrakt: Chromoblastomycosis (CBM) is a chronic subcutaneous infection caused by melanotic fungi, affecting mainly rural workers in tropical and subtropical regions. Secondary bacterial infections (SBIs) in CBM lesions bring complications to the disease, but little is known about the agents involved. Fungal and bacterial identification and epidemiological profile of 50 patients with CBM were analyzed in this study. Bacteria were tested for susceptibility to antibacterial drugs. Fonseacea pedrosoi and Rhinocladiella aquaspersa were the fungal agents isolated. 88% of the patients presented SBI. Gram-positive bacteria coinfected mainly upper limbs, and Gram-negative bacteria were more isolated from lower limbs. Streptococcus pyogenes and mixed bacterial microbiota were associated with severe lesions. Staphylococcus aureus was associated with mixed infections and consequently with the severity of the infection. Resistance to β-lactams and methicillin was detected. Our results emphasize the necessity of bacterial culture and susceptibility testing as part of routine monitoring CBM cases.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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