Training Induced Oxidative Stress-Derived DNA and Muscle Damage in Triathletes.

Autor: Zainudin H; Centre for Research and Innovation Management, National Defence University of Malaysia, Kuala Lumpur, Malaysia., Caszo BA; School of Medicine, International Medical University, Kuala Lumpur, Malaysia., Knight VF; School of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia., Gnanou JV; School of Medicine and Defence Health, National Defence University of Malaysia, Kuala Lumpur, Malaysia.
Jazyk: angličtina
Zdroj: The Eurasian journal of medicine [Eurasian J Med] 2019 Jun; Vol. 51 (2), pp. 116-120.
DOI: 10.5152/eurasianjmed.2019.18106
Abstrakt: Objective: Regular moderate-intensity exercise has beneficial health effects, whereas regular strenuous exercise increases the production of oxidants that may lead to DNA, skeletal, and cardiac muscle damages. Triathletes experience strenuous muscular activity both during competition and training, being at risk of developing these tissue damages. The objective of the present study was to estimate DNA, skeletal, and cardiac muscle damages using blood biomarkers, 8-hydroxy-2'-deoxyguanosine (8-OHdG), myoglobin, and cardiac troponin I (cTnI) among young triathletes.
Materials and Methods: Age-matched seven male and seven female triathletes were recruited for the study. They were on a standardized training regimen and on average competed in at least one endurance event every month for the past 3-4 years. Serum biomarkers were measured using enzyme-linked immunosorbent assay at the start and at end of the racing season.
Results: Both male and female triathletes showed a statistically significant increase in 8-OHdG. A similar pattern of increase was seen with serum myoglobin, which was not statistically significant in both male and female triathletes. cTnI levels did not show any change in both sexes.
Conclusion: Our study shows that there could be an increased evidence of DNA damage among triathletes. However, similar effects were not observed with skeletal and cardiac muscle biomarkers.
Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare.
Databáze: MEDLINE
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