| Autor: |
Maragheh AD; a Department of Biology , Islamic Azad University, Mashhad Branch , Mashhad , Iran., Tabrizi MH; a Department of Biology , Islamic Azad University, Mashhad Branch , Mashhad , Iran., Karimi E; a Department of Biology , Islamic Azad University, Mashhad Branch , Mashhad , Iran., Seyedi SMR; b Department of Biology, Faculty of Sciences , Ferdowsi University of Mashhad , Mashhad , Iran.; c Department of Chemistry, Faculty of Sciences , Ferdowsi University of Mashhad , Mashhad , Iran., Khatamian N; a Department of Biology , Islamic Azad University, Mashhad Branch , Mashhad , Iran. |
| Abstrakt: |
Aims: The sour cherry pit oil (SCPO) displays the potent anti-inflammatory, and antioxidant activities. In the present study, we have produced the SCPO nanoemulsion (SCPO-NE) to evaluate their anticancer impacts on breast cancer comparing with its un-processed oil. Methods: We employed an ultrasonication method to formulate the stable SCPO-NE. Their size, stability, and morphology were measured. Then, their cytotoxic impacts and apoptotic activity were checked on MCF7 breast cancer cells and compared with the normal Human foreskin fibroblasts (HFF). Finally, their anti-tumour effect was studied on murine breast cancer model (inoculated with TUBO cancer cells). Results: The results indicated the 36.5 nm stable SCPO-NE significantly decreased the MCF7 cells viability comparing with normal HFF cells, and reduced the tumour size in the murine model. Conclusion: We suggest that SCPO-NEs are able to efficiently inhibit breast cancer progression in both MCF7 cells and murine breast cancer model through apoptotic death induction. |
