| Autor: |
Rahlwes KC; Department of Microbiology, University of Massachusetts, 639 North Pleasant Street, Amherst, MA, 01003, USA., Sparks IL; Department of Microbiology, University of Massachusetts, 639 North Pleasant Street, Amherst, MA, 01003, USA., Morita YS; Department of Microbiology, University of Massachusetts, 639 North Pleasant Street, Amherst, MA, 01003, USA. ymorita@microbio.umass.edu. |
| Jazyk: |
angličtina |
| Zdroj: |
Sub-cellular biochemistry [Subcell Biochem] 2019; Vol. 92, pp. 417-469. |
| DOI: |
10.1007/978-3-030-18768-2_13 |
| Abstrakt: |
Actinobacteria is a group of diverse bacteria. Most species in this class of bacteria are filamentous aerobes found in soil, including the genus Streptomyces perhaps best known for their fascinating capabilities of producing antibiotics. These bacteria typically have a Gram-positive cell envelope, comprised of a plasma membrane and a thick peptidoglycan layer. However, there is a notable exception of the Corynebacteriales order, which has evolved a unique type of outer membrane likely as a consequence of convergent evolution. In this chapter, we will focus on the unique cell envelope of this order. This cell envelope features the peptidoglycan layer that is covalently modified by an additional layer of arabinogalactan . Furthermore, the arabinogalactan layer provides the platform for the covalent attachment of mycolic acids , some of the longest natural fatty acids that can contain ~100 carbon atoms per molecule. Mycolic acids are thought to be the main component of the outer membrane, which is composed of many additional lipids including trehalose dimycolate, also known as the cord factor. Importantly, a subset of bacteria in the Corynebacteriales order are pathogens of human and domestic animals, including Mycobacterium tuberculosis. The surface coat of these pathogens are the first point of contact with the host immune system, and we now know a number of host receptors specific to molecular patterns exposed on the pathogen's surface, highlighting the importance of understanding how the cell envelope of Actinobacteria is structured and constructed. This chapter describes the main structural and biosynthetic features of major components found in the actinobacterial cell envelopes and highlights the key differences between them. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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