Subcortical Substrates of Explore-Exploit Decisions in Primates.

Autor:	Costa VD; Laboratory of Neuropsychology, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA; Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR 97006, USA. Electronic address: costav@ohsu.edu., Mitz AR; Laboratory of Neuropsychology, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA., Averbeck BB; Laboratory of Neuropsychology, National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892, USA.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2019 Aug 07; Vol. 103 (3), pp. 533-545.e5. Date of Electronic Publication: 2019 Jun 10.
DOI:	10.1016/j.neuron.2019.05.017
Abstrakt:	The explore-exploit dilemma refers to the challenge of deciding when to forego immediate rewards and explore new opportunities that could lead to greater rewards in the future. While motivational neural circuits facilitate learning based on past choices and outcomes, it is unclear whether they also support computations relevant for deciding when to explore. We recorded neural activity in the amygdala and ventral striatum of rhesus macaques as they solved a task that required them to balance novelty-driven exploration with exploitation of what they had already learned. Using a partially observable Markov decision process (POMDP) model to quantify explore-exploit trade-offs, we identified that the ventral striatum and amygdala differ in how they represent the immediate value of exploitative choices and the future value of exploratory choices. These findings show that subcortical motivational circuits are important in guiding explore-exploit decisions. (Published by Elsevier Inc.)
Databáze:	MEDLINE
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