Early motor resonance differentiates schizophrenia patients from healthy subjects and predicts social cognition performance.

Autor:	Mehta UM; Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bengaluru, India. Electronic address: urvakhsh@gmail.com., Ashok AH; Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neurosciences, Kings College London, London, United Kingdom., Thirthalli J; Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bengaluru, India., Keshavan MS; Massachusetts Mental Health Center & Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Jazyk:	angličtina
Zdroj:	Progress in brain research [Prog Brain Res] 2019; Vol. 247, pp. 353-374. Date of Electronic Publication: 2019 Mar 28.
DOI:	10.1016/bs.pbr.2019.03.011
Abstrakt:	Background: Diminished motor resonance (facilitation of motor potentials during action observation) is possibly related to social cognition deficits in schizophrenia. Adequate social cognition requires the successful moment-to-moment appraisal of social stimuli over a temporal window. However, similar changes in motor resonance with successive action observation stimuli are unknown. We compared the time-course of motor resonance evoked during successive action observation stimuli between schizophrenia patients (antipsychotic-naïve and medicated) and healthy subjects and examined its association with social cognition performance. Method: Fifty-four schizophrenia patients (33 antipsychotic-naive) and 45 healthy subjects underwent 10-recordings (T1 to T10) of cortical reactivity, using two single (sp)- and two paired-pulse (pp) transcranial magnetic stimulation (TMS) paradigms, while they observed goal-directed actions and a static image. They also underwent comprehensive social cognition assessments. Results: Sp-motor resonance revealed a significant quadratic time effect (initial fall and then rise) in patients and healthy subjects [F=12.21, P=0.001]. Such a pattern was not observed for pp-motor resonance. We categorized motor resonance as early (T1-T3), middle (T4-T7) and late (T8-T10) based on pair-wise comparisons. Early, but not middle or late sp-motor resonance was reduced in antipsychotic naïve patients compared to the medicated patients and healthy subjects (F=3.41, P=0.037). Social cognition composite score had significant correlations with both early sp-motor resonance (r=0.34, P=0.01) and early pp-motor resonance (r=0.314, P=0.02) in the combined patient group. Conclusions: Motor resonance time-courses did not vary across groups. The magnitude of early motor resonance was reduced in the antipsychotic-naïve schizophrenia group, compared to healthy subjects. Early phase motor resonance was associated with social cognition deficits in patients. (© 2019 Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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