Phase Separation as a Melting Pot for DNA Repeats.

Autor: Hall AC; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ONT, M5G 1M1, Canada., Ostrowski LA; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ONT, M5G 1M1, Canada., Mekhail K; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 661 University Avenue, Toronto, ONT, M5G 1M1, Canada; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, ONT, M5S 1A8, Canada. Electronic address: karim.mekhail@utoronto.ca.
Jazyk: angličtina
Zdroj: Trends in genetics : TIG [Trends Genet] 2019 Aug; Vol. 35 (8), pp. 589-600. Date of Electronic Publication: 2019 May 31.
DOI: 10.1016/j.tig.2019.05.001
Abstrakt: Genome expression and stability are dependent on biological processes that control repetitive DNA sequences and nuclear compartmentalization. The phase separation of macromolecules has recently emerged as a major player in the control of biological pathways. Here, we summarize recent studies that collectively reveal intersections between phase separation, repetitive DNA elements, and nuclear compartments. These intersections modulate fundamental processes, including gene expression, DNA repair, and cellular lifespan, in the context of health and diseases such as cancer and neurodegeneration.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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