Routing information flow by separate neural synchrony frequencies allows for "functionally labeled lines" in higher primate cortex.

Autor:	Khamechian MB; Neuroscience and Neuroengineering Research Laboratory, Biomedical Engineering Department, School of Electrical Engineering, Iran University of Science and Technology (IUST), Narmak, 16846-13114 Tehran, Iran; treue@gwdg.de daliri@iust.ac.ir., Kozyrev V; Cognitive Neuroscience Laboratory, German Primate Center - Leibniz Institute for Primate Research, 37077 Goettingen, Germany.; Bernstein Center for Computational Neuroscience, 37077 Goettingen, Germany., Treue S; Cognitive Neuroscience Laboratory, German Primate Center - Leibniz Institute for Primate Research, 37077 Goettingen, Germany; treue@gwdg.de daliri@iust.ac.ir.; Bernstein Center for Computational Neuroscience, 37077 Goettingen, Germany.; Faculty of Biology and Psychology, University of Goettingen, 37073 Goettingen, Germany.; Leibniz-ScienceCampus Primate Cognition, 37077 Goettingen, Germany., Esghaei M; Cognitive Neuroscience Laboratory, German Primate Center - Leibniz Institute for Primate Research, 37077 Goettingen, Germany.; School of Cognitive Sciences, Institute for Research in Fundamental Sciences, 19395 Tehran, Iran., Daliri MR; Neuroscience and Neuroengineering Research Laboratory, Biomedical Engineering Department, School of Electrical Engineering, Iran University of Science and Technology (IUST), Narmak, 16846-13114 Tehran, Iran; treue@gwdg.de daliri@iust.ac.ir.; School of Cognitive Sciences, Institute for Research in Fundamental Sciences, 19395 Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Jun 18; Vol. 116 (25), pp. 12506-12515. Date of Electronic Publication: 2019 May 30.
DOI:	10.1073/pnas.1819827116
Abstrakt:	Efficient transfer of sensory information to higher (motor or associative) areas in primate visual cortical areas is crucial for transforming sensory input into behavioral actions. Dynamically increasing the level of coordination between single neurons has been suggested as an important contributor to this efficiency. We propose that differences between the functional coordination in different visual pathways might be used to unambiguously identify the source of input to the higher areas, ensuring a proper routing of the information flow. Here we determined the level of coordination between neurons in area MT in macaque visual cortex in a visual attention task via the strength of synchronization between the neurons' spike timing relative to the phase of oscillatory activities in local field potentials. In contrast to reports on the ventral visual pathway, we observed the synchrony of spikes only in the range of high gamma (180 to 220 Hz), rather than gamma (40 to 70 Hz) (as reported previously) to predict the animal's reaction speed. This supports a mechanistic role of the phase of high-gamma oscillatory activity in dynamically modulating the efficiency of neuronal information transfer. In addition, for inputs to higher cortical areas converging from the dorsal and ventral pathway, the distinct frequency bands of these inputs can be leveraged to preserve the identity of the input source. In this way source-specific oscillatory activity in primate cortex can serve to establish and maintain "functionally labeled lines" for dynamically adjusting cortical information transfer and multiplexing converging sensory signals. Competing Interests: The authors declare no conflict of interest. (Copyright © 2019 the Author(s). Published by PNAS.)
Databáze:	MEDLINE
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