Pharmacokinetics of oral and subcutaneous meloxicam: Effect on indicators of pain and inflammation after knife castration in weaned beef calves.

Autor: Meléndez DM; Lethbridge Research Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta, Canada., Marti S; Lethbridge Research Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta, Canada.; Department of Ruminant Production, IRTA, Caldes de Montbui, Barcelona, Spain., Pajor EA; Department of Production Animal Health, University of Calgary, Calgary, Alberta, Canada., Sidhu PK; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, United States of America., Gellatly D; Lethbridge Research Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta, Canada., Janzen ED; Department of Production Animal Health, University of Calgary, Calgary, Alberta, Canada., Schwinghamer TD; Lethbridge Research Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta, Canada., Coetzee JF; Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, United States of America., Schwartzkopf-Genswein KS; Lethbridge Research Centre, Agriculture and Agri-Food Canada, Lethbridge, Alberta, Canada.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2019 May 24; Vol. 14 (5), pp. e0217518. Date of Electronic Publication: 2019 May 24 (Print Publication: 2019).
DOI: 10.1371/journal.pone.0217518
Abstrakt: Oral meloxicam is labelled for reducing pain and inflammation associated with castration in cattle in Canada, however, subcutaneous meloxicam is only labelled for pain associated with dis-budding and abdominal surgery. The aim of this project was to determine the pharmacokinetic profile of oral (PO; 1.0 mg/kg BW) and subcutaneous meloxicam (SC; 0.5 mg/kg BW), and to assess the effect of meloxicam on physiological and behavioural indicators of pain associated with knife castration in 7-8 month old calves. Twenty-three Angus crossbred beef calves (328 ± 4.4 kg BW) were randomly assigned to two treatments: PO n = 12 or SC n = 11 administration of meloxicam immediately before knife castration. Physiological parameters included salivary and hair cortisol, substance P, haptoglobin, serum amyloid-A, weight, complete blood count, scrotal and rectal temperature. Behavioural parameters included standing and lying behaviour, pen behaviour and feeding behaviour. Data were analyzed using PROC GLIMMIX (SAS), with repeated measures using mixed procedures including treatment as a fixed effect and animal and pen as a random effect. The pharmacokinetic profile of the drug including area under the curve, volume of distribution and clearance was greater (P < 0.05) in PO than SC calves. After surgery, substance P concentrations, white blood cell counts (WBC), weight and lying duration were greater (P < 0.05) in PO than SC calves, while scrotal circumference was lower (P < 0.05) in PO calves than SC calves. Although statistical differences were observed for pharmacokinetic, physiological and behavioural parameters differences were small and may lack biological relevance.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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