Compensation of retinal nerve fibre layer thickness as assessed using optical coherence tomography based on anatomical confounders.

Autor:	Chua J; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Schwarzhans F; Section for Medical Information Management and Imaging, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria., Nguyen DQ; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Sia JT; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Lim C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Mathijia S; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore, Singapore., Cheung C; Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong., Tin A; Singapore National Eye Centre, Singapore, Singapore., Fischer G; Section for Medical Information Management and Imaging, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria., Cheng CY; Ocular Epidemiology Research Group, Singapore Eye Research Institute, Singapore, Singapore., Vass C; Ophthalmology, Medical University of Vienna, Vienna, Austria., Schmetterer L; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria leopold.schmetterer@seri.com.sg.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2020 Feb; Vol. 104 (2), pp. 282-290. Date of Electronic Publication: 2019 May 22.
DOI:	10.1136/bjophthalmol-2019-314086
Abstrakt:	Background/aims: To compensate the retinal nerve fibre layer (RNFL) thickness assessed by spectral-domain optical coherence tomography (SD-OCT) for anatomical confounders. Methods: The Singapore Epidemiology of Eye Diseases is a population-based study, where 2698 eyes (1076 Chinese, 704 Malays and 918 Indians) with high-quality SD-OCT images from individuals without eye diseases were identified. Optic disc and macular cube scans were registered to determine the distance between fovea and optic disc centres (fovea distance) and their respective angle (fovea angle). Retinal vessels were segmented in the projection images and used to calculate the circumpapillary retinal vessel density profile. Compensated RNFL thickness was generated based on optic disc (ratio, orientation and area), fovea (distance and angle), retinal vessel density, refractive error and age. Linear regression models were used to investigate the effects of clinical factors on RNFL thickness. Results: Retinal vessel density reduced significantly with increasing age (1487±214 µm in 40-49, 1458±208 µm in 50-59, 1429±223 µm in 60-69 and 1415±233 µm in ≥70). Compensation reduced the variability of RNFL thickness, where the effect was greatest for Chinese (10.9%; p<0.001), followed by Malays (6.6%; p=0.075) and then Indians (4.3%; p=0.192). Compensation reduced the age-related RNFL decline by 55% in all participants (β=-3.32 µm vs β=-1.50 µm/10 years; p<0.001). Nearly 62% of the individuals who were initially classified as having abnormally thin RNFL (outside the 99% normal limits) were later reclassified as having normal RNFL. Conclusions: RNFL thickness compensated for anatomical parameters reduced the variability of measurements and may improve glaucoma detection, which needs to be confirmed in future studies. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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