Clinical and endoscopic aspects of metastases to the gastrointestinal tract.

Autor:	Haendchen Bento L; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Kazuyoshi Minata M; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Pires Batista C; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Martins BDC; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Lenz Tolentino LH; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Scomparim RC; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Shiguehissa Kawaguti F; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Gusmon de Oliveira CC; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Simas de Lima M; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Naschold Geiger S; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Ryoka Baba E; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Safatle-Ribeiro A; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Ribeiro U Jr; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil., Maluf-Filho F; Instituto do Câncer do Estado de São Paulo, São Paulo, Brasil.
Jazyk:	angličtina
Zdroj:	Endoscopy [Endoscopy] 2019 Jul; Vol. 51 (7), pp. 646-652. Date of Electronic Publication: 2019 May 14.
DOI:	10.1055/a-0887-4401
Abstrakt:	Background: Studies that describe metastases to the gastrointestinal (GI) tract are restricted to small case series. An increase in the frequency of this condition is expected, so it would be useful to better characterize the endoscopic aspects of metastasis to the GI tract. The aims of this study were to describe the frequency and endoscopic features of the lesions, and to analyze the survival rate after diagnosis of metastasis. Methods: This was a retrospective, single-center, observational study, conducted between 2009 and 2017. Patients with metastasis to the GI tract were included. Results: 95 patients were included. Melanoma (25.3 %), lung (15.8 %), and breast (14.7 %) were the most frequent primary tumors. The most common endoscopic presentation was a solitary, ulcerated lesion in the gastric body. Conventional biopsy was diagnostic in 98.9 % of the cases. The mean and median survival rates were 13.3 months (95 % confidence interval [CI] 8.2 - 18.3) and 4.7 months (95 %CI 3.7 - 5.6), respectively. Palliative treatment with chemo- and/or radiotherapy after the diagnosis of the metastasis was related to a higher survival rate. Conclusions: Melanoma, lung, and breast cancer were the most common primary tumors to metastasize to the GI tract. The endoscopic features could not predict the primary site of the tumor. The finding of metastasis in the GI tract is related to the final stage of the cancer disease but patients who received palliative treatment with chemo- and/or radiotherapy after diagnosis of GI metastasis had higher survival rates. Competing Interests: None. (© Georg Thieme Verlag KG Stuttgart · New York.)
Databáze:	MEDLINE
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