Postpartum use of oxytocin and volume of placental transfusion: a randomised controlled trial.

Autor:	Vain NE; Pediatrics, Hospital Trinidad, University of Buenos Aires, Buenos Aires, Argentina.; Fundasamin, Buenos Aires, Argentina., Satragno DS; Fundasamin, Buenos Aires, Argentina.; Neonatology, Hospital de Ninos Ricardo Gutierrez, Buenos Aires, Argentina., Gordillo JE; Neonatology, Instituto de Maternidad y Ginecología Nuestra Señora de Las Mercedes, Tucumán, Argentina., Fernandez AL; Fundasamin, Buenos Aires, Argentina., Carrolli G; Centro Rosarino de Estudios Perinatales, Rosario, Argentina., Romero NP; Neonatology, Instituto de Maternidad y Ginecología Nuestra Señora de Las Mercedes, Tucumán, Argentina., Prudent LM; Fundasamin, Buenos Aires, Argentina.
Jazyk:	angličtina
Zdroj:	Archives of disease in childhood. Fetal and neonatal edition [Arch Dis Child Fetal Neonatal Ed] 2020 Jan; Vol. 105 (1), pp. 14-17. Date of Electronic Publication: 2019 May 09.
DOI:	10.1136/archdischild-2018-316649
Abstrakt:	Objective: To assess whether oxytocin administered before clamping the umbilical cord modifies the volume of placental transfusion. Design: Randomised controlled trial. Methods: Mothers of term infants born vigorous by vaginal delivery with informed consent provided in early labour were randomly assigned to oxytocin (10 IU) given intravenously within 15 s of birth (group 1) or after clamping the umbilical cord 3 min after delivery (group 2). Soon after birth, all infants were weighed using a 1 g precision scale and subsequently placed on the mother's abdomen or chest. At 3 min, in both groups, the cord was clamped and cut, and the weight was again obtained. The primary outcome (volume of placental transfusion) was estimated by the difference in weights. Results: 144 patients were included. There were no differences in the primary outcome: infants in group 1 (n=70) gained a mean weight of 85.9 g (SD 48.3), and in group 2 (n=74) 86.7 g (SD 49.6) (p=0.92). No differences were found in secondary outcomes, including newborns' haematocrit and bilirubin concentrations and severe maternal postpartum haemorrhage. On the advice of the Data and Safety Monitoring Committee, the trial was stopped due to futility at 25% of the planned sample size. Conclusions: When umbilical cord clamping is delayed for 3 min, term newborn infants born vigorous receive a clinically significant placental transfusion which is not modified by the administration of intravenous oxytocin immediately after birth. Trial Registration Number: NCT02618499. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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