Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation.

Autor: Grade CVC; 1Universidade Federal da Integração Latino-Americana, UNILA, Instituto Latino-Americano de Ciências da Vida e da Natureza, Avenida Tarquínio Joslin dos Santos, 1000, Foz do Iguaçu, PR CEP 85870-901 Brazil., Mantovani CS; 2Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas - UNICAMP, Rua Monteiro Lobato, 255, Campinas, SP CEP 13083-862 Brazil., Alvares LE; 2Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas - UNICAMP, Rua Monteiro Lobato, 255, Campinas, SP CEP 13083-862 Brazil.
Jazyk: angličtina
Zdroj: Journal of animal science and biotechnology [J Anim Sci Biotechnol] 2019 Apr 23; Vol. 10, pp. 32. Date of Electronic Publication: 2019 Apr 23 (Print Publication: 2019).
DOI: 10.1186/s40104-019-0338-5
Abstrakt: Myostatin (MSTN) is one of the key factors regulating myogenesis. Because of its role as a negative regulator of muscle mass deposition, much interest has been given to its protein and, in recent years, several studies have analysed MSTN gene regulation. This review discusses the MSTN gene promoter, focusing on its structure in several animal species, both vertebrate and invertebrate. We report the important binding sites considering their degree of phylogenetic conservation and roles they play in the promoter activity. Finally, we discuss recent studies focusing on MSTN gene regulation via promoter manipulation and the potential applications they have both in medicine and agriculture.
Competing Interests: Not applicable.Not applicable.The authors declare that they have no competing interests.
Databáze: MEDLINE
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