A rare case of TLE1-positive sclerosing epithelioid fibrosarcoma expanding the differential diagnosis of TLE1-positive tumors: a case report.
| Autor: | Perez D; Department of Pathology, SUNY Upstate Medical University, Syracuse, New York 13210, USA., Fullmer JM; Department of Pathology, Beaumont Hospital, Royal Oak, MI 48073, USA., Naous R; Department of Pathology, SUNY Upstate Medical University, Syracuse, New York 13210, USA. |
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| Jazyk: | angličtina |
| Zdroj: | AME case reports [AME Case Rep] 2019 Mar 05; Vol. 3, pp. 6. Date of Electronic Publication: 2019 Mar 05 (Print Publication: 2019). |
| DOI: | 10.21037/acr.2019.02.01 |
| Abstrakt: | Transducin-like enhancer of split 1 (TLE1) is a transcription factor known for its strong overexpression and immunopositivity in synovial sarcoma. Several studies have revealed that its immunopositivity is not always specific to synovial sarcoma, with several cases showing positivity in peripheral nerve sheath tumors and solitary fibrous tumors. Occasional weak staining for TLE1 has also been described in clear cell sarcoma, high-grade chondrosarcoma, Ewing sarcoma, rhabdomyosarcoma, GIST, myxofibrosarcoma, and leiomyosarcoma. Here we present the first unique case of sclerosing epithelioid fibrosarcoma with strong, diffuse TLE1 positivity, resulting in a new consideration for the differential diagnosis of TLE1 positivity. Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare. |
| Databáze: | MEDLINE |
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