The antidepressant effect of bone marrow mononuclear cell transplantation in chronic stress.

Autor:	do Prado-Lima PAS; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., Onsten GA; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., de Oliveira GN; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., Brito GC; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., Ghilardi IM; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., de Souza EV; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., Dos Santos PG; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., Salamoni SD; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., Machado DC; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., Duarte MMF; 2 Laboratório de Biogenômica, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil., Barbisan F; 2 Laboratório de Biogenômica, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil., da Cruz IBM; 2 Laboratório de Biogenômica, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, Brazil., Costa-Ferro ZSM; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil., daCosta JC; 1 Brain Institute (BraIns), PUCRS, Porto Alegre, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2019 May; Vol. 33 (5), pp. 632-639. Date of Electronic Publication: 2019 Apr 25.
DOI:	10.1177/0269881119841562
Abstrakt:	Background: Inflammation could be a risk factor for the development of depression and change the outcome of this common chronic-recurrent mental disorder. Aims: This study aimed to investigate if bone marrow mononuclear cell (BMMC) transplantation is effective in restoring sucrose preference in rats subjected to chronic stress (CS), if it has an anti-inflammatory effect and is able to restore damaged DNA. Methods: The effect of BMMC transplantation was studied in a controlled protocol (compared with a control group and a selective serotonin reuptake inhibitor escitalopram group) involving sucrose preference in CS in rats. Measurements were taken of the amygdala, hippocampus, frontal cortex, and other brain areas, the spleen and blood pro-inflammatory cytokines, namely interleukin-1β, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma, as well as anti-inflammatory cytokine interleukin-10. Finally, 8-hydroxy-2'-deoxyguanosine (a DNA damage marker) was determined. Results: BMMC transplantation was as effective as escitalopram in restoring sucrose preference. It also had an anti-inflammatory effect and slightly improved damaged DNA after one week. Conclusions: These findings suggest administration of BMMC in rats subjected to CS restores sucrose preference, resolves inflammation in both the peripheral and central nervous system, as well as diminishes DNA damage. This effect was similar to that of escitalopram, which is effective in the treatment of depressive patients.
Databáze:	MEDLINE
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