Anverenes B⁻E, New Polyhalogenated Monoterpenes from the Antarctic Red Alga Plocamium cartilagineum .

Autor: Shilling AJ; Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE205, Tampa, FL 33620, USA. ashillin@mail.usf.edu., von Salm JL; Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE205, Tampa, FL 33620, USA. j.vs.fries@gmail.com., Sanchez AR; Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 E. Fowler Ave., ISA2015, Tampa, FL 33620, USA. ars1@mail.usf.edu., Kee Y; Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, 4202 E. Fowler Ave., ISA2015, Tampa, FL 33620, USA. ykee@usf.edu., Amsler CD; Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. amsler@uab.edu., McClintock JB; Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. mcclinto@uab.edu., Baker BJ; Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE205, Tampa, FL 33620, USA. bjbaker@usf.edu.
Jazyk: angličtina
Zdroj: Marine drugs [Mar Drugs] 2019 Apr 17; Vol. 17 (4). Date of Electronic Publication: 2019 Apr 17.
DOI: 10.3390/md17040230
Abstrakt: The subtidal red alga Plocamium cartilagineum was collected from the Western Antarctic Peninsula during the 2011 and 2017 austral summers. Bulk collections from specific sites corresponded to chemogroups identified by Young et al. in 2013. One of the chemogroups yielded several known acyclic halogenated monoterpenes ( 2 - 5 ) as well as undescribed compounds of the same class, anverenes B-D ( 6 - 8 ). Examination of another chemogroup yielded an undescribed cyclic halogenated monoterpene anverene E ( 9 ) as its major secondary metabolite. Elucidation of structures was achieved through one-dimensional (1D) and 2D nuclear magnetic resonance (NMR) spectroscopy and negative chemical ionization mass spectrometry. Compounds 1 - 9 show moderate cytotoxicity against cervical cancer (HeLa) cells.
Databáze: MEDLINE
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