Bullous systemic lupus erythematosus - a case report.

Autor:	Padrão EMH; Universidade de São Paulo, Medical School, Department of Internal Medicine. São Paulo, SP, Brazil., Teixeira LF; Universidade de São Paulo, Medical School, Department of Internal Medicine. São Paulo, SP, Brazil., Maruta CW; Universidade de São Paulo, Medical School, Department of Dermatology. São Paulo, SP, Brazil., Aoki V; Universidade de São Paulo, Medical School, Department of Dermatology. São Paulo, SP, Brazil., Felipe da Silva AS; Universidade de São Paulo, University Hospital Pathology. São Paulo, SP, Brazil.; Universidade de São Paulo, Department of Pathology. São Paulo, SP, Brazil., Kim EIM; Universidade de São Paulo, Hospital Universitário, Department of Internal Medcine. São Paulo, SP, Brazil., Smelli LA; Universidade de São Paulo, Hospital Universitário, Department of Internal Medcine. São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Autopsy & case reports [Autops Case Rep] 2019 Feb 25; Vol. 9 (1), pp. e2018069. Date of Electronic Publication: 2019 Feb 25 (Print Publication: 2019).
DOI:	10.4322/acr.2018.069
Abstrakt:	Skin involvement in systemic lupus erythematosus (SLE) occurs in more than 75% of patients with this condition. Vesicles and blisters in lupus erythematosus (LE) may be present in SLE secondary to interface vacuolar changes in the epidermis, in discoid LE also secondary to vacuolar epidermal changes, and in bullous LE secondary to antibodies anti-collagen VII deposits with neutrophilic aggregates. In addition, blisters can occur due to the association of SLE with other autoimmune blistering diseases (e.g. bullous pemphigoid). BSLE is a rare blistering disease that mainly occurs in females (30-40 years old), and less frequently in children and adolescents. The most common presentation is rapid and widespread development of tense vesicles and bullae over erythematous macules or plaques. Preferential sites are: superior trunk, proximal superior limbs, and face (lips) with symmetrical distribution. Mucosal involvement is common on perioral, pharyngeal, laryngeal, and genital areas. The involvement of sun-exposed areas is not mandatory. The lesions usually progress with no scarring, but hypo or hyperchromia may be present. We report an 18-year-old female patient with blistering lesions at admission, who was diagnosed with BSLE. She was initially treated with systemic prednisone and hydroxychloroquine. Her condition evolved with relapsing lesions, which required the introduction of Dapsone. The authors emphasize the relevance of recognizing BSLE-a rare presentation of SLE-which may evolve with marked clinical presentation. Competing Interests: Conflict of interest: None
Databáze:	MEDLINE
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