Determination by chromatography and cytotoxotoxic and oxidative effects of pyriproxyfen and pyridalyl.

Autor: Alves PES; Post-Graduation Department in Chemistry, State University of Piauí, zip code 64003-120, Teresina, Piauí, Brazil. Electronic address: patriciaesilvalves@gmail.com., Oliveira MDDA; Chemistry Departament, Federal University of Piauí, zip code 64000-040, Teresina, Piauí, Brazil., Marcos de Almeida P; Post-Graduation Department in Chemistry, State University of Piauí, zip code 64003-120, Teresina, Piauí, Brazil., Martins FA; Post-Graduation Department in Chemistry, State University of Piauí, zip code 64003-120, Teresina, Piauí, Brazil., Amélia de Carvalho Melo Cavalcante A; Post-Graduation Department in Pharmacy, Federal University of Piauí, zip code 64049-550, Teresina, Piauí, Brazil., de Jesus Aguiar Dos Santos Andrade T; Nucleus of Applied Research to Sciences (NIAC), Federal Institute of Maranhão, Campus Timon, zip code 65630-000, Maranhão, Brazil., Feitosa CM; Chemistry Departament, Federal University of Piauí, zip code 64000-040, Teresina, Piauí, Brazil., Rai M; Biotechnology Departament, Sant Gadge Baba Amravati University, Amravati, 444 602, Maharashtra, India., Campinho Dos Reis A; Post-Graduation Department in Pharmacy, Federal University of Piauí, zip code 64049-550, Teresina, Piauí, Brazil., Soares da Costa Júnior J; Federal Institute of Piauí (IFPI), Teresina, PI, Brazil.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2019 Jun; Vol. 224, pp. 398-406. Date of Electronic Publication: 2019 Feb 11.
DOI: 10.1016/j.chemosphere.2019.02.037
Abstrakt: Pyriproxyfen (PPF) is a larvicide, used to combat the proliferation of Aedes aegypti larvae. The objective of this study was to analyze the compounds of pyriproxyfen and pyridalyl (PYL) in a commercial larvicide to analyze the cytotoxic and oxidative effects of PPF and PYL. The toxic potential of PPF and PYL were assessed based on lethal concentration (LC 50 ) in Artemia salina, cytotoxicity based on the mitotic index and the chromosomal alterations in Allium cepa and the oxidative damage in Saccharomyces cerevisiae. The PPF and PYL compounds were identified by HPLC-PDA based on their retention times and spectral data. The wavelengths λ max (258 nm) and (271 nm) of the UV spectrum of PYL and PPF and the retention times (R T ) (3.38 min) and (4.03 min), respectively. The toxicological potentials of PPF and PYL were significant at concentrations (1, 10, 100 and 1000 ppm), with an LC 50 of 48 h (0.5 ppm). PPF and PYL pointed out a cytotoxic effect in A. cepa at all concentrations (0.0001, 0.001, 0.01, 0.1, 1.0, 100 and 1000 ppm), genotoxic effect at concentrations only (0.0001; 0.1; 1; 100 and 1000 ppm), and mutagenic for concentrations (0.1, 100 and 1000 ppm). In relation S. cerevisiae, PPF e PYL prompted oxidative damage at concentrations (100 and 1000 ppm) in all strains (SODWT, Sod1, Sod2, Sod1Sod2, Cat1 and Sod1Cat1). Therefore, the PPF and PYL identificated in commercial larvicide by HPLC-PDA produced cytotoxic and oxidative effects that could cause health and ecosystem risks.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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