[The advantage of test on thrombin generation for evaluation of hemostasis potential under implementation of coronary bypass surgery in patients with ischemic heart disease.]

Autor:	Gruzdeva OV; The research institute of complex problems of cardiovascular diseases, 650002, Kemerovo, Russia., Fanaskova EV; The research institute of complex problems of cardiovascular diseases, 650002, Kemerovo, Russia., Akbasheva OE; The Sibirskii state medical university of Minzdrav of Russia, 634050, Tomsk, Russia., Uchasova EG; The research institute of complex problems of cardiovascular diseases, 650002, Kemerovo, Russia., Penskaya TY; The research institute of complex problems of cardiovascular diseases, 650002, Kemerovo, Russia., Dyleva YA; The research institute of complex problems of cardiovascular diseases, 650002, Kemerovo, Russia., Kuzmina AA; The research institute of complex problems of cardiovascular diseases, 650002, Kemerovo, Russia., Barbarash OL; The research institute of complex problems of cardiovascular diseases, 650002, Kemerovo, Russia.; The Kemerovskaia state medical academy of Minzdrav of Russia, 650029, Kemerovo, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2017; Vol. 62 (9), pp. 545-552.
DOI:	10.18821/0869-2084-2017-62-9-545-552
Abstrakt:	The purpose of study is to evaluate peri-operational parameters of testing of generation of thrombin and its relationship with indices of coagulation hemostasis, fibrinolytic system and anti-coagulants in patients with ischemic heart disease under coronary bypass surgery in conditions of artificial blood circulation. The examined sampling included 200 patients with ischemic heart disease. The planned primary operation of coronary bypass surgery in conditions of artificial blood circulation was applied to all of them. The testing of generation of thrombin was implemented using automated analyzer CEVERON-ALPHA (Technoclone, Vienna, Austria). The indices of testing of generation of thrombin were compared with common techniques of evaluation of hemostasis (INR, PTT, fibrinogen, Qick's prothrombin testing, thrombin time, AT-III, protein C, factor VIII), von Willebrand factor, inhibitor of activation of plasminogen type I (PAI-I), tissue and urokinase plasminogen activator. It is demonstrated that application of testing of thrombin generation duplicates enumerated indices and permits at the same time instant to detect both pro-coagulation and anti-thrombotic shifts. The advantage of testing of thrombin generation is in evaluation of thrombin potential that is most actual in cardiologic practice. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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