Atherogenic cytokines and chemokines in chronic hepatitis C are not associated with the presence of cardiovascular diseases.

Autor: Santos TPS; Programa de Pós-Graduação em Imunologia, Universidade Federal da Bahia, Brazil., Pereira MM; Programa de Pós-Graduação em Imunologia, Universidade Federal da Bahia, Brazil., Schinoni MI; Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Brazil., Sampaio GP; Programa de Pós-Graduação em Imunologia, Universidade Federal da Bahia, Brazil., Aras R Jr; Hospital Universitário Prof. Edgard Santos, Universidade Federal da Bahia, Brazil., Atta MLS; Faculdade de Farmácia, Laboratório de Pesquisa em Imunologia, Universidade Federal da Bahia, Brazil., Atta AM; Faculdade de Farmácia, Laboratório de Pesquisa em Imunologia, Universidade Federal da Bahia, Brazil. Electronic address: ajaxmatta@gmail.com.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2019 Mar; Vol. 115, pp. 24-31. Date of Electronic Publication: 2019 Feb 14.
DOI: 10.1016/j.cyto.2018.12.005
Abstrakt: There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CHC patients. Twenty-six CHC patients, 35 individuals with atherosclerosis (Athero) and 27 healthy individuals were examined for risk factors for CVD, lipid profile, atherogenic risk indexes, and insulin resistance (IR). Cardiac biomarkers and the chemokines and cytokines involved in atherosclerosis were also evaluated. A higher prevalence of prior acute myocardial infarction was found in the Athero group. Most CHC patients were infected with the hepatitis C virus genotype 1 and exhibited either no hepatic fibrosis or a mild to moderate liver fibrosis. The apolipoprotein B/apolipoprotein A-I and triglyceride/high-density lipoprotein cholesterol ratios and C-reactive protein levels were lower in CHC patients than in the Athero group. Further, IR was elevated in the CHC group and associated with the waist circumference. High GDF-15 levels were observed in the CHC group, which were inversely correlated with APOB levels. Peripheral blood mononuclear cells from CHC patients produced more IFN-γ, TNF-α and IL-6 than CAD PBMC but the production of IL-10 and IL-1β was similar. CHC and CAD groups presented similar levels of IL-8, MCP-1 and LAP-TGF-β1. Increased IR, elevated levels of GDF-15, and high production of atherogenic cytokines can be observed in Brazilian CHC patients without association with diabetes and clinical manifestation of cardiovascular diseases.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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