Methionine Gamma Lyase from Clostridium sporogenes Increases the Anticancer Efficacy of Doxorubicin on A549 Cancer Cells In Vitro and Human Cancer Xenografts.

Autor:	Pokrovsky VS; Laboratory of Combined Treatment, N.N. Blokhin Cancer Research Center, Moscow, Russia. vadimpokrovsky@gmail.com.; Department of Biochemistry, People's Friendship University (RUDN University), Moscow, Russia. vadimpokrovsky@gmail.com., Anisimova NY; Laboratory of Combined Treatment, N.N. Blokhin Cancer Research Center, Moscow, Russia., Davydov DZ; Laboratory of Combined Treatment, N.N. Blokhin Cancer Research Center, Moscow, Russia., Bazhenov SV; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia.; Laboratory of Molecular Genetics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia., Bulushova NV; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia., Zavilgelsky GB; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia., Kotova VY; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia., Manukhov IV; State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia.; Laboratory of Molecular Genetics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia.
Jazyk:	angličtina
Zdroj:	Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2019; Vol. 1866, pp. 243-261.
DOI:	10.1007/978-1-4939-8796-2_18
Abstrakt:	The anticancer efficacy of methionine γ-lyase (MGL) from Clostridium sporogenes (C. sporogenes) is described. MGL was active against cancer cells in vitro and in vivo. Doxorubicin (DOX) and MGL were more effective on A549 human lung-cancer growth inhibition than either agent alone in vitro and in vivo.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu