[The evaluation of genotoxic effects in buccal epithelium under disorders of adaption status of organism.]

Autor:	Deryugina AV; The Federal State Autonomous Educational Institution of Higher Education 'Lobachevsky State university of Nizhny Novgorod', 603950, Nizhny Novgorod, Russia., Ivashchenko MN; The Federal State Budget Educational Institution of Higher Education 'The Nizhny Novgorod State Agricultural Academy' of Minselkhoz of Russia, 603950, Nizhny Novgorod, Russia., Ignatiev PS; The Joint-Stock Company 'The Production Association 'The E.S. Yalamov Ural Optical Mechanical Plant', 620100, Yekaterinburg, Russia., Samodelkin AG; The Federal State Budget Educational Institution of Higher Education 'The Nizhny Novgorod State Agricultural Academy' of Minselkhoz of Russia, 603950, Nizhny Novgorod, Russia., Belov AA; The Federal State Budget Educational Institution of Higher Education 'The Nizhny Novgorod State Medical Academy' of Minzdrav of Russia, 603081, Nizhny Novgorod, Russia., Gushchin VA; The Federal State Budget Educational Institution of Higher Education 'The Nizhny Novgorod State Agricultural Academy' of Minselkhoz of Russia, 603950, Nizhny Novgorod, Russia.
Jazyk:	ruština
Zdroj:	Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2018; Vol. 63 (5), pp. 290-292.
DOI:	10.18821/0869-2084-2018-63-5-290-292
Abstrakt:	The cyto-morphologic analysis of buccal epithelium is one of technique of evaluation of adaptation status of organism and xenogeneic intoxication. The analysis of reactivity of cells of buccal epithelium is used to obtain information concerning genetic alterations in human cells that is extremely important for proper decision making related to issues of population health protection. The smoking results in manifestation of tension of adaptation mechanisms and significant increasing of risk of development cytogenetic disorders in cells of buccal epithelium of oral cavity. The study was carried out concerning morphology of buccal epithelial cells of smoking youths. The cytogram demonstrated a reliable decreasing of number of normal cells and increasing of percentage of cells with various cytogenetic alterations. The cells with micro-nuclei are observed twice more often that can be considered as an integral indicator of genetic disorders in inter phase. In smokers, among cells with signs of completion of nucleus destruction the cells with karyorrhexis are registered reliably more often. The results of micro-nucleus test are an unfavorable prognostic indication testifying high degree of genotoxicity of tobacco smoke and meaning a disorder of cytogenetic homeostasis and decreasing of adaptation reserve of organism. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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